Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/101025
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Carvalho, João | - |
dc.contributor.author | Nunes, Pedro | - |
dc.contributor.author | Silva, Edgar Tavares da | - |
dc.contributor.author | Silva, Rodolfo | - |
dc.contributor.author | Lima, João | - |
dc.contributor.author | Quaresma, Vasco | - |
dc.contributor.author | Figueiredo, Arnaldo | - |
dc.date.accessioned | 2022-07-26T09:12:01Z | - |
dc.date.available | 2022-07-26T09:12:01Z | - |
dc.date.issued | 2021-03-18 | - |
dc.identifier.issn | 2282-4197 | pt |
dc.identifier.issn | 1124-3562 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/101025 | - |
dc.description.abstract | Objectives: Clinical approach of prostate cancer (PCa) biochemical recurrence (BCR) is an ever-changing topic. Prostate-specific membrane antigen positron emission tomography ([68Ga]Ga-PSMA-11 PET-CTPSMA PET-CT) has shown good potential in this field. The aim is to evaluate PSMA PET-CT detection rate in PCa BCR and assess its impact on clinical outcome. Material and methods: Out of 319 patients with PCa who underwent PSMA PET-CT between October 2015 and June 2019, 70 had developed BCR after treatment with curative intent. Two groups were created: one with BCR after surgery (RP group) (N: 48; 68.6%) and other with BCR after radiotherapy (RT group) (N: 22; 31.4%). Clinical, analytical, pathological and PSMA PET-CT results were evaluated. Results: Initial age was different between groups (p = 0.008). RP patients were mainly at intermediate risk (85.1% vs 42.9%, p = 0.001) while RT patients were at low risk of recurrence (8.5% vs 47.6%, p = 0.001). In RP and RT groups, PSMA PETCT detected, respectively, pelvic relapse in 31.3% and 63.6%, and extrapelvic relapse in 18.8% and 31.8%. Salvage treatment was performed in 61.9% (n = 26) of RP patients and in 15% (n = 3) of RT patients, p < 0.001. Of RP patients submitted to salvage treatment, 59.1% achieved complete remission. Concerning these patients, local radiotherapy led to complete remission in 68.4% (n = 13). Of RT patients submitted to salvage treatment, two had complete remission and one had partial remission.Concerning detection rate, PSMA PET-CT was positive for pelvic relapse when pre-PET PSA ≥ 0.8 ng/mL (RP) or ≥ 2.3 ng/mL (RT) and for extrapelvic relapse when PSA ≥ 0.4 ng/mL (RP) or ≥ 3.5 ng/mL (RT), p > 0.05. Conclusions: Biochemical persistence rate after salvage therapy was similar (30-40%). The cut-off PSA values for pelvic relapse detected on PSMA PET-CT were ≥ 0.8 ng/mL (RP) and ≥ 2.3 ng/mL (RT). | pt |
dc.language.iso | eng | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt |
dc.subject.mesh | Aged | pt |
dc.subject.mesh | Cross-Sectional Studies | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Middle Aged | pt |
dc.subject.mesh | Neoplasm Recurrence, Local | pt |
dc.subject.mesh | Prostate-Specific Antigen | pt |
dc.subject.mesh | Prostatic Neoplasms | pt |
dc.subject.mesh | Gallium Isotopes | pt |
dc.subject.mesh | Gallium Radioisotopes | pt |
dc.subject.mesh | Positron Emission Tomography Computed Tomography | pt |
dc.subject.mesh | Radiopharmaceuticals | pt |
dc.title | [68Ga]Ga-PSMA-11 PET-CT: Local preliminary experience in prostate cancer biochemical recurrence patients | pt |
dc.type | article | - |
degois.publication.firstPage | 21 | pt |
degois.publication.lastPage | 25 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Archivio Italiano di Urologia e Andrologia | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.4081/aiua.2021.1.21 | pt |
degois.publication.volume | 93 | pt |
dc.date.embargo | 2021-03-18 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.orcid | 0000-0002-3038-0492 | - |
crisitem.author.orcid | 0000-0002-4538-199X | - |
crisitem.author.orcid | 0000-0002-7157-0081 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
68GaGaPSMA11-PETCT-Local-preliminary-experience-in-prostate-cancer-biochemical-recurrence-patientsArchivio-Italiano-di-Urologia-e-Andrologia.pdf | 513.82 kB | Adobe PDF | View/Open |
WEB OF SCIENCETM
Citations
1
checked on May 2, 2023
Page view(s)
153
checked on Oct 2, 2024
Download(s)
105
checked on Oct 2, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License