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Title: | Multifunctionalization of cyanuric chloride for the stepwise synthesis of potential multimodal imaging chemical entities | Authors: | Calvete, Mário J. F. Pinto, Sara M. A. Burrows, Hugh D. Castro, M. Margarida C. A. Geraldes, Carlos F. G. C. Pereira, Mariette M. |
Keywords: | Porphyrins; Aza-chelates; Sulfonation; Fluorescence; Biomedicinal applications; Cyanuric chloride | Issue Date: | 2020 | Project: | PEst-OE/QUI/UI0313/2014, UID/QUI/00313/2013 PTDC/QEQ-MED/3521/2014 SFRH/BPD/84619/2012 SFRH/ BPD/99698/2014 |
Serial title, monograph or event: | Arabian Journal of Chemistry | Volume: | 13 | Issue: | 1 | Abstract: | We report a synthetic strategy to combine different moieties in a single structure using cyanuric chloride (2,4,6-trichlorotriazine) as a starting platform for preparing potential bioimaging agents. This reacted with macrocycles of the porphyrin family and DOTA type metal chelators through mono-, di- and tri- substitution of its chlorine atoms by appropriate nucleophiles, control- ling the stepwise by temperature, to produce a system that opens the potential for biomedicinal applications. Porphyrins were chosen as one of the sensing arms, based on their rich structural chemistry, and excellent photophysical properties, while DO3A was used since it can form a versa- tile aminopropionate functionalized metal ion chelator. All new compounds were fully character- ized, both spectroscopically and photophysically | URI: | https://hdl.handle.net/10316/101359 | ISSN: | 18785352 | DOI: | 10.1016/j.arabjc.2018.06.005 | Rights: | openAccess |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais I&D CQC - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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