Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/103222
Title: | Proteome dataset of sea bass (Dicentrarchus labrax) skin-scales exposed to fluoxetine and estradiol | Authors: | Anjos, Liliana Pinto, Patrícia I. S. Santos, Soraia Estêvão, M. Dulce Santa, Cátia Manadas, Bruno Canário, Adelino V. M. Power, Deborah M. |
Keywords: | SWATH-MS quantitative proteomics; Scales Emerging pollutants Antidepressant Estrogen | Issue Date: | Apr-2022 | Project: | UIDB/04326/2020 PTDC/AAG-GLO/4003/2012 |
Serial title, monograph or event: | Data in Brief | Volume: | 41 | Abstract: | Contamination of aquatic ecosystems with anthropogenic pollutants, including pharmaceutical drugs, is a major concern worldwide. Aquatic organisms such as fish are particularly at risk of exposure to pollutants. The surface of fish is the first point of contact with pollutants, but few studies have considered the impact of pollutants on the skin-scale barrier. The present proteome data are the basis of the findings discussed in the associated research article "Proteomics of sea bass skin-scales exposed to the emerging pollutant fluoxetine compared to estradiol" [1]. Juvenile sea bass were exposed by intraperitoneal injections to: a) the antidepressant fluoxetine (FLX), a widely prescribed psychotropic drug and an emerging pollutant; b) the natural estrogen 17β-estradiol (E2) and c) the vehicle, coconut oil (control). The scale proteome of fish exposed to these compounds for 5 days was analysed using quantitative label-free proteomics technology SWATH-MS (sequential windowed data-independent acquisition of the total high-resolution-mass spectra). The proteome data generated was submitted to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD020983. LC-MS data from pooled protein extracts from the scales of all experimental groups was acquired using information-dependent acquisition (IDA) and 1,254 proteins were identified by searching against the sea bass genome database. 715 proteins were quantified by SWATH acquisition, and 213 proteins had modified levels (p < 0.05) between the E2- or FLX-exposed fish compared to the control. The main biological processes and KEGG pathways affected by E2 or FLX treatments were identified using Cytoscape/ClueGO enrichment analyses. | URI: | https://hdl.handle.net/10316/103222 | ISSN: | 23523409 | DOI: | 10.1016/j.dib.2022.107971 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1-s2.0-S2352340922001822-main.pdf | 735.2 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
1
checked on Jul 8, 2024
Page view(s)
124
checked on Sep 4, 2024
Download(s)
90
checked on Sep 4, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License