Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/105304
Title: | Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics | Authors: | Nunes, Sara Viana, Sofia D. Preguiça, Inês Alves, André Fernandes, Rosa Teodoro, João S. Matos, Patrícia Figueirinha, Artur Salgueiro, Lígia André, Alexandra Silva, Sara Jarak, Ivana Carvalho, Rui A. Cavadas, Cláudia Rolo, Anabela P. Palmeira, Carlos M. Pintado, Maria M. Reis, Flávio |
Keywords: | blueberries; hypercaloric diet-induced prediabetes; gut microbiota; hepatic energy metabolism; mitochondria function; hepatoprotection | Issue Date: | 23-Nov-2021 | Publisher: | MDPI | Project: | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/NEU/04539/2013/PT info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/NEU/04539/2019/PT UIDB/04539/2020 UIDB/50006/2020 UIDP/04539/2020 info:eu-repo/grantAgreement/SFRH/BD/109017/2015 PTDC/SAU-NUT/31712/2017 CEECIND/04400/2017 REEQ/481/QUI/2006 RECI/QEQ-QFI/0168/2012 CENTRO-07-CT62-FEDER-002012 |
Serial title, monograph or event: | Nutrients | Volume: | 13 | Issue: | 12 | Abstract: | The paramount importance of a healthy diet in the prevention of type 2 diabetes is now well recognized. Blueberries (BBs) have been described as attractive functional fruits for this purpose. This study aimed to elucidate the cellular and molecular mechanisms pertaining to the protective impact of blueberry juice (BJ) on prediabetes. Using a hypercaloric diet-induced prediabetic rat model, we evaluated the effects of BJ on glucose, insulin, and lipid profiles; gut microbiota composition; intestinal barrier integrity; and metabolic endotoxemia, as well as on hepatic metabolic surrogates, including several related to mitochondria bioenergetics. BJ supplementation for 14 weeks counteracted diet-evoked metabolic deregulation, improving glucose tolerance, insulin sensitivity, and hypertriglyceridemia, along with systemic and hepatic antioxidant properties, without a significant impact on the gut microbiota composition and related mechanisms. In addition, BJ treatment effectively alleviated hepatic steatosis and mitochondrial dysfunction observed in the prediabetic animals, as suggested by the amelioration of bioenergetics parameters and key targets of inflammation, insulin signaling, ketogenesis, and fatty acids oxidation. In conclusion, the beneficial metabolic impact of BJ in prediabetes may be mainly explained by the rescue of hepatic mitochondrial bioenergetics. These findings pave the way to support the use of BJ in prediabetes to prevent diabetes and its complications. | URI: | https://hdl.handle.net/10316/105304 | ISSN: | 2072-6643 | DOI: | 10.3390/nu13124192 | Rights: | openAccess |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais I&D CERES - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Blueberry-counteracts-prediabetes-in-a-hypercaloric-dietinduced-rat-model-and-rescues-hepatic-mitochondrial-bioenergeticsNutrients.pdf | 4.8 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
10
checked on Sep 23, 2024
WEB OF SCIENCETM
Citations
9
checked on Sep 2, 2024
Page view(s)
114
checked on Sep 25, 2024
Download(s)
34
checked on Sep 25, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License