Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/105530
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Martins, Beatriz | - |
dc.contributor.author | Amorim, Madania | - |
dc.contributor.author | Reis, Flávio | - |
dc.contributor.author | Ambrósio, António Francisco | - |
dc.contributor.author | Fernandes, Rosa | - |
dc.date.accessioned | 2023-03-06T10:49:02Z | - |
dc.date.available | 2023-03-06T10:49:02Z | - |
dc.date.issued | 2020-08-04 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | https://hdl.handle.net/10316/105530 | - |
dc.description.abstract | Diabetic retinopathy (DR) is a complex, progressive, and heterogenous retinal degenerative disease associated with diabetes duration. It is characterized by glial, neural, and microvascular dysfunction, being the blood-retinal barrier (BRB) breakdown a hallmark of the early stages. In advanced stages, there is formation of new blood vessels, which are fragile and prone to leaking. This disease, if left untreated, may result in severe vision loss and eventually legal blindness. Although there are some available treatment options for DR, most of them are targeted to the advanced stages of the disease, have some adverse effects, and many patients do not adequately respond to the treatment, which demands further research. Oxidative stress and low-grade inflammation are closely associated processes that play a critical role in the development of DR. Retinal cells communicate with each other or with another one, using cell junctions, adhesion contacts, and secreted soluble factors that can act in neighboring or long-distance cells. Another mechanism of cell communication is via secreted extracellular vesicles (EVs), through exchange of material. Here, we review the current knowledge on deregulation of cell-to-cell communication through EVs, discussing the changes in miRNA expression profiling in body fluids and their role in the development of DR. Thereafter, current and promising therapeutic agents for preventing the progression of DR will be discussed. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | CENTRO-01-0145-FEDER-000008: BRAINHEALTH 2020 | pt |
dc.relation | CENTRO-01-0145-FEDER-000012: HealthyAging2020 | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | UIDP/04539/2020 (CIBB) | pt |
dc.relation | PTDC/SAU-NUT/31712/2017 | pt |
dc.relation | POCI-01-0145-FEDER-007440 | pt |
dc.relation | POCI-01-0145-FEDER-031712 | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/NEU/04539/2019/PT | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | diabetic retinopathy (DR) | pt |
dc.subject | inflammation | pt |
dc.subject | oxidative stress | pt |
dc.subject | angiogenesis | pt |
dc.subject | extracellular vesicles | pt |
dc.subject | miRNA | pt |
dc.subject | biomarkers | pt |
dc.subject | antioxidants | pt |
dc.title | Extracellular Vesicles and MicroRNA: Putative Role in Diagnosis and Treatment of Diabetic Retinopathy | pt |
dc.type | article | pt |
degois.publication.firstPage | 705 | pt |
degois.publication.issue | 8 | pt |
degois.publication.title | Antioxidants | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/antiox9080705 | - |
degois.publication.volume | 9 | pt |
dc.date.embargo | 2020-08-04 | * |
dc.identifier.pmid | 32759750 | - |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology | - |
crisitem.project.grantno | CNC. IBILI | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0002-2132-3461 | - |
crisitem.author.orcid | 0000-0002-8653-5705 | - |
crisitem.author.orcid | 0000-0003-3401-9554 | - |
crisitem.author.orcid | 0000-0002-0477-1641 | - |
crisitem.author.orcid | 0000-0001-7828-2296 | - |
Aparece nas coleções: | I&D ICBR - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Extracellular-vesicles-and-microrna-Putative-role-in-diagnosis-and-treatment-of-diabetic-retinopathyAntioxidants.pdf | 1.45 MB | Adobe PDF | Ver/Abrir |
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