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https://hdl.handle.net/10316/106469
Title: | Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives | Authors: | Gomes, Ana T. P. C. Fernandes, Rosa Ribeiro, Carlos F. M. Tomé, João P. C. Neves, Maria G. P. M. S. Silva, Fernando de C. da Ferreira, Vítor F. Cavaleiro, José A. S. |
Keywords: | porphyrin; triazole; polyvinylpyrrolidone; photodynamic therapy; human bladder cancer cells; human retinal pigment epithelial cells | Issue Date: | 31-Mar-2020 | Publisher: | MDPI | metadata.degois.publication.title: | Molecules | metadata.degois.publication.volume: | 25 | metadata.degois.publication.issue: | 7 | Abstract: | Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells. | URI: | https://hdl.handle.net/10316/106469 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules25071607 | Rights: | openAccess |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais |
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