Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/106489
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gierlich, Piotr | - |
dc.contributor.author | Mata, Ana I. | - |
dc.contributor.author | Donohoe, Claire | - |
dc.contributor.author | Brito, Rui M. M. | - |
dc.contributor.author | Senge, Mathias O. | - |
dc.contributor.author | Silva, Lígia C. Gomes da | - |
dc.date.accessioned | 2023-04-05T09:05:24Z | - |
dc.date.available | 2023-04-05T09:05:24Z | - |
dc.date.issued | 2020-11-14 | - |
dc.identifier.issn | 1420-3049 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/106489 | - |
dc.description.abstract | Photodynamic therapy (PDT) is a promising cancer treatment which involves a photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which combine to elicit cell death. While the illumination required to activate a PS imparts a certain amount of selectivity to PDT treatments, poor tumor accumulation and cell internalization are still inherent properties of most intravenously administered PSs. As a result, common consequences of PDT include skin photosensitivity. To overcome the mentioned issues, PSs may be tailored to specifically target overexpressed biomarkers of tumors. This active targeting can be achieved by direct conjugation of the PS to a ligand with enhanced affinity for a target overexpressed on cancer cells and/or other cells of the tumor microenvironment. Alternatively, PSs may be incorporated into ligand-targeted nanocarriers, which may also encompass multi-functionalities, including diagnosis and therapy. In this review, we highlight the major advances in active targeting of PSs, either by means of ligand-derived bioconjugates or by exploiting ligand-targeting nanocarriers. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | Science Foundation Ireland (SFI P.I. 13/IA/1894) | pt |
dc.relation | FCT - MedChemTrain PhD programme, grant PD/00147/2013 | pt |
dc.relation | UID/QUI/00313/2019 | pt |
dc.relation | Marie Skłodowska-Curie | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | photodynamic therapy | pt |
dc.subject | cancer | pt |
dc.subject | drug delivery | pt |
dc.subject | active targeting | pt |
dc.subject | nanocarriers | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Ligands | pt |
dc.subject.mesh | Nanoparticles | pt |
dc.subject.mesh | Neoplasms | pt |
dc.subject.mesh | Peptides | pt |
dc.subject.mesh | Photosensitizing Agents | pt |
dc.subject.mesh | Drug Delivery Systems | pt |
dc.title | Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment | pt |
dc.type | article | - |
degois.publication.firstPage | 5317 | pt |
degois.publication.issue | 22 | pt |
degois.publication.title | Molecules | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/molecules25225317 | pt |
degois.publication.volume | 25 | pt |
dc.date.embargo | 2020-11-14 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-9508-7035 | - |
crisitem.author.orcid | 0000-0001-9128-2557 | - |
crisitem.author.orcid | 0000-0003-0624-8819 | - |
Appears in Collections: | I&D CQC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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LigandTargeted-Delivery-of-Photosensitizers-for-Cancer-TreatmentMolecules.pdf | 1.49 MB | Adobe PDF | View/Open |
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