Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/107177
DC Field | Value | Language |
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dc.contributor.author | Chavarria, Daniel | - |
dc.contributor.author | Fernandes, Carlos | - |
dc.contributor.author | Aguiar, Brandon | - |
dc.contributor.author | Silva, Tiago | - |
dc.contributor.author | Garrido, Jorge | - |
dc.contributor.author | Remião, Fernando | - |
dc.contributor.author | Oliveira, Paulo J. | - |
dc.contributor.author | Uriarte, Eugenio | - |
dc.contributor.author | Borges, Fernanda | - |
dc.date.accessioned | 2023-06-13T09:57:46Z | - |
dc.date.available | 2023-06-13T09:57:46Z | - |
dc.date.issued | 2019-12-02 | - |
dc.identifier.issn | 1420-3049 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/107177 | - |
dc.description.abstract | Exogenous antioxidants may be beneficial therapeutic tools to tackle the oxidative damage in neurodegenerative diseases by regulation of the redox state that is critical for cell viability and organ function. Inspired by natural plant polyphenols, a series of cinnamic acid-based thiophenolic and phenolic compounds were synthesized and their antioxidant and neuroprotective properties were studied. In general, our results showed that the replacement of the hydroxyl group (OH) by a sulfhydryl group (SH) increased the radical scavenging activity and enhanced the reaction rate with 1,1-diphenyl-2-picrylhydrazyl radical (DPPH•) and galvinoxyl radical (GO•). These results correlated well with the lower oxidation potential (Ep) values of thiophenols. However, a lower peroxyl radical (ROO•) scavenging activity was observed for thiophenols in oxygen radical absorbance capacity (ORAC-FL) assay. Furthermore, the introduction of 5-methoxy and 5-phenyl groups in the aromatic ring of 4-thioferulic acid (TFA) 2 and ferulic acid (FA) 1 did not significantly improve their antioxidant activity, despite the slight decrease of Ep observed for compounds 5, 6, and 9. Concerning cinnamic acid amides, the antioxidant profile was similar to the parent compounds. None of the compounds under study presented significant cytotoxic effects in human differentiated neuroblastoma cells. Thiophenolic amide 3 stands out as the most promising thiophenol-based antioxidant, showing cellular neuroprotective effects against oxidative stress inducers (hydrogen peroxide and iron). | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | UID/QUI/00081 | pt |
dc.relation | NORTE-01–0145-FEDER-000028 | pt |
dc.relation | POCI-01–0145-FEDER-029164 | pt |
dc.relation | FCT, POPH and FEDER/COMPETE and NORTE-01-0145-FEDER-000028 | pt |
dc.relation | COST Action CA15135 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | cinnamic acid | pt |
dc.subject | 4-thioferulic acid derivatives | pt |
dc.subject | ferulic acid derivatives | pt |
dc.subject | antioxidant activity | pt |
dc.subject | cytotoxicity | pt |
dc.subject | neuroprotection | pt |
dc.subject.mesh | Antioxidants | pt |
dc.subject.mesh | Cell Line, Tumor | pt |
dc.subject.mesh | Chemical Phenomena | pt |
dc.subject.mesh | Cinnamates | pt |
dc.subject.mesh | Free Radical Scavengers | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Molecular Structure | pt |
dc.subject.mesh | Neuroprotective Agents | pt |
dc.subject.mesh | Oxidation-Reduction | pt |
dc.subject.mesh | Phenols | pt |
dc.subject.mesh | Structure-Activity Relationship | pt |
dc.subject.mesh | Sulfhydryl Compounds | pt |
dc.subject.mesh | Drug Discovery | pt |
dc.title | Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues | pt |
dc.type | article | - |
degois.publication.firstPage | 4405 | pt |
degois.publication.issue | 23 | pt |
degois.publication.title | Molecules | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/molecules24234405 | pt |
degois.publication.volume | 24 | pt |
dc.date.embargo | 2019-12-02 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-8981-231X | - |
crisitem.author.orcid | 0000-0002-5201-9948 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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Insights-into-the-discovery-of-novel-neuroprotective-agents-A-comparative-study-between-sulfanylcinnamic-acid-derivatives-and-related-phenolic-analoguesMolecules.pdf | 2.93 MB | Adobe PDF | View/Open |
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