Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/107236
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nunes, Ana | - |
dc.contributor.author | Silva, Gilberto | - |
dc.contributor.author | Duque, Cristina | - |
dc.contributor.author | Januário, Cristina | - |
dc.contributor.author | Santana, Isabel | - |
dc.contributor.author | Ambrósio, António | - |
dc.contributor.author | Castelo-Branco, Miguel | - |
dc.contributor.author | Bernardes, Rui | - |
dc.date.accessioned | 2023-06-15T11:19:32Z | - |
dc.date.available | 2023-06-15T11:19:32Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1932-6203 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/107236 | - |
dc.description.abstract | A top priority in biomarker development for Alzheimer's disease (AD) and Parkinson's disease (PD) is the focus on early diagnosis, where the use of the retina is a promising avenue of research. We computed fundus images from optical coherence tomography (OCT) data and analysed the structural arrangement of the retinal tissue using texture metrics. We built clinical class classification models to distinguish between healthy controls (HC), AD, and PD, using machine learning (support vector machines). Median sensitivity is 88.7%, 79.5% and 77.8%, for HC, AD, and PD eyes, respectively. When the same subject has the same classification for both eyes, 94.4% (median) of the classifications are correct. A significant amount of information discriminating between multiple neurodegenerative states is conveyed by OCT imaging of the human retina, even when differences in thickness are not yet present. This technique may allow for simultaneously diagnosing Alzheimer's and Parkinson's diseases. | pt |
dc.language.iso | por | pt |
dc.publisher | Public Library of Science | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Aged | pt |
dc.subject.mesh | Alzheimer Disease | pt |
dc.subject.mesh | Case-Control Studies | pt |
dc.subject.mesh | Diagnosis, Differential | pt |
dc.subject.mesh | Diagnostic Techniques, Ophthalmological | pt |
dc.subject.mesh | Disease Progression | pt |
dc.subject.mesh | Early Diagnosis | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Fundus Oculi | pt |
dc.subject.mesh | Health | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Middle Aged | pt |
dc.subject.mesh | Nerve Fibers | pt |
dc.subject.mesh | Parkinson Disease | pt |
dc.subject.mesh | Predictive Value of Tests | pt |
dc.subject.mesh | Retina | pt |
dc.subject.mesh | Support Vector Machine | pt |
dc.subject.mesh | Tomography, Optical Coherence | pt |
dc.subject.mesh | Biomarkers | pt |
dc.subject.mesh | Diagnostic Techniques, Neurological | pt |
dc.title | Retinal texture biomarkers may help to discriminate between Alzheimer's, Parkinson's, and healthy controls | pt |
dc.type | article | - |
degois.publication.firstPage | e0218826 | pt |
degois.publication.issue | 6 | pt |
degois.publication.title | PLoS ONE | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1371/journal.pone.0218826 | pt |
degois.publication.volume | 14 | pt |
dc.date.embargo | 2019-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | pt | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CIBIT - Coimbra Institute for Biomedical Imaging and Translational Research | - |
crisitem.author.researchunit | CIBIT - Coimbra Institute for Biomedical Imaging and Translational Research | - |
crisitem.author.orcid | 0000-0001-5402-3978 | - |
crisitem.author.orcid | 0000-0002-8114-9434 | - |
crisitem.author.orcid | 0000-0002-0477-1641 | - |
crisitem.author.orcid | 0000-0003-4364-6373 | - |
crisitem.author.orcid | 0000-0002-6677-2754 | - |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D ICNAS - Artigos em Revistas Internacionais I&D CIBIT - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Retinal-texture-biomarkers-may-help-to-discriminate-between-Alzheimers-Parkinsons-and-healthy-controlsPLoS-ONE.pdf | 1.15 MB | Adobe PDF | View/Open |
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