Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/107431
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cabral, Ana M. T. D. P. V. | - |
dc.contributor.author | Fernandes, Ana C. G. | - |
dc.contributor.author | Veiga, Francisco | - |
dc.contributor.author | Sofio, Sara P. C. | - |
dc.contributor.author | Paiva, Isabel | - |
dc.contributor.author | Esteso, Miguel Á. | - |
dc.contributor.author | Rodrigo, M. Melia | - |
dc.contributor.author | Valente, Artur J. M. | - |
dc.contributor.author | Ribeiro, Ana C. F. | - |
dc.date.accessioned | 2023-07-11T10:39:45Z | - |
dc.date.available | 2023-07-11T10:39:45Z | - |
dc.date.issued | 2022-06-01 | - |
dc.identifier.issn | 2305-6304 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/107431 | - |
dc.description.abstract | The formation of complexes of the drug 5-fluorouracil (5-FU) with β-cyclodextrin (β-CD) and sodium dodecyl sulphate (SDS) was studied through experimental measurements of the ternary mutual diffusion coefficients (D11, D22, D12, and D21) for the systems {5-FU (component 1) + β-CD (component 2) + water} and {5-FU (component 1) + SDS (component 2) + water} at 298.15 K and at concentrations up to 0.05 mol dm-3 by using the Taylor dispersion method, with the objective of removing this polluting drug from the residual systems in which it was present. The results found showed that a coupled diffusion of 5-FU occurred with both β-CD and SDS, as indicated by the nonzero values of the cross-diffusion coefficients, D12 and D21, as a consequence of the complex formation between 5-FU and the β-CD or SDS species. That is, 5-FU was solubilized (encapsulated) by both carriers, although to a greater extent with SDS (K = 20.0 (±0.5) mol-1 dm3) than with β-CD (K = 10.0 (±0.5) mol-1 dm3). Values of 0.107 and 0.190 were determined for the maximum fraction of 5-FU solubilized with β-CD and SDS (at concentrations above its CMC), respectively. This meant that SDS was more efficient at encapsulating and thus removing the 5-FU drug. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | UID/QUI/UI0313/2019 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | 5-fluorouracil | pt |
dc.subject | complexation | pt |
dc.subject | diffusion coefficients | pt |
dc.subject | sodium dodecyl sulphate | pt |
dc.subject | β-cyclodextrin | pt |
dc.title | Complexation of 5-Fluorouracil with β-Cyclodextrin and Sodium Dodecyl Sulfate: A Useful Tool for Encapsulating and Removing This Polluting Drug | pt |
dc.type | article | - |
degois.publication.firstPage | 300 | pt |
degois.publication.issue | 6 | pt |
degois.publication.title | Toxics | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/toxics10060300 | pt |
degois.publication.volume | 10 | pt |
dc.date.embargo | 2022-06-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CEGOT – Centre of Studies on Geography and Spatial Planning | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-2912-0028 | - |
crisitem.author.orcid | 0000-0002-1041-0068 | - |
crisitem.author.orcid | 0000-0003-2005-8990 | - |
crisitem.author.orcid | 0000-0001-6872-1611 | - |
crisitem.author.orcid | 0000-0001-9736-3999 | - |
crisitem.author.orcid | 0000-0002-4612-7686 | - |
crisitem.author.orcid | 0000-0002-3005-1963 | - |
Appears in Collections: | I&D CEGOT - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais I&D CQC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Cabral2022Toxics.pdf | 337.42 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
2
checked on Sep 30, 2024
WEB OF SCIENCETM
Citations
2
checked on Oct 2, 2024
Page view(s)
116
checked on Oct 1, 2024
Download(s)
77
checked on Oct 1, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License