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https://hdl.handle.net/10316/107626
Title: | Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies | Authors: | Guedes, Joana R. Lao, Taotao Cardoso, Ana L. El Khoury, Joseph |
Keywords: | Alzheimer's disease; amyloid-β peptide; chemokine receptors; chemokines; microglia; monocytes; neuroinflammation; protein tau | Issue Date: | 2018 | Publisher: | Frontiers Media S.A. | Project: | NIH grants 1RF1 AG051506 and R01 AI119065 PhD fellowship (SFRH/BD/51677/2011) Post-doctoral fellowship (SFRH/BPD/120611/2016 SFRH/BPD/108312/2015 |
Serial title, monograph or event: | Frontiers in Neurology | Volume: | 9 | Abstract: | Chemokines and their receptors have been shown to affect amyloid-β (Aβ) and tau pathologies in mouse models of Alzheimer's disease (AD) by regulating microglia and monocyte-associated neuroinflammation, microglial movement and monocyte recruitment into the brain. These cells in turn can promote and mediate Aβ phagocytosis and degradation and tau phosphorylation. In this review we discuss published work in this field in mouse models of AD and review what is known about the contributions of microglial and monocyte chemokines and their receptors to amyloid and tau pathologies. We focus on the roles of the chemokine/chemokine receptor pairs CCL2/CCR2, CX3CL1/CX3CR1, CCL5/CCR5, CXCL10/CXCR3 and CXCL1/CXCR2, highlighting important knowledge gaps in this field. A full understanding of the functions of chemokines and their receptors in AD may guide the development of novel immunotherapies for this devastating disease. | URI: | https://hdl.handle.net/10316/107626 | ISSN: | 1664-2295 | DOI: | 10.3389/fneur.2018.00549 | Rights: | openAccess |
Appears in Collections: | IIIUC - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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