Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/107632
Campo DC | Valor | Idioma |
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dc.contributor.author | Kerkhofs, Amber | - |
dc.contributor.author | Canas, Paula M. | - |
dc.contributor.author | Timmerman, A. J. | - |
dc.contributor.author | Heistek, Tim S. | - |
dc.contributor.author | Real, Joana I. | - |
dc.contributor.author | Xavier, Carolina | - |
dc.contributor.author | Cunha, Rodrigo A. | - |
dc.contributor.author | Mansvelder, Huibert D. | - |
dc.contributor.author | Ferreira, Samira G. | - |
dc.date.accessioned | 2023-07-25T09:50:31Z | - |
dc.date.available | 2023-07-25T09:50:31Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1663-9812 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/107632 | - |
dc.description.abstract | Adenosine A2A receptors (A2AR) are activated upon increased synaptic activity to assist in the implementation of long-term plastic changes at synapses. While it is reported that A2AR are involved in the control of prefrontal cortex (PFC)-dependent behavior such as working memory, reversal learning and effort-based decision making, it is not known whether A2AR control glutamatergic synapse plasticity within the medial PFC (mPFC). To elucidate that, we tested whether A2AR blockade affects long-term plasticity (LTP) of excitatory post-synaptic potentials in pyramidal neurons and fast spiking (FS) interneurons in layer 5 of the mPFC and of population spikes. Our results show that A2AR are enriched at mPFC synapses, where their blockade reversed the direction of plasticity at excitatory synapses onto layer 5 FS interneurons from LTP to long-term depression, while their blockade had no effect on the induction of LTP at excitatory synapses onto layer 5 pyramidal neurons. At the network level, extracellularly induced LTP of population spikes was reduced by A2AR blockade. The interneuron-specificity of A2AR in controlling glutamatergic synapse LTP may ensure that during periods of high synaptic activity, a proper excitation/inhibition balance is maintained within the mPFC. | pt |
dc.description.sponsorship | Supported by Maratona da Saúde, Santa Casa da Misericórdia, GAI-FMUC and Banco Santander-Totta, NARSAD, Erasmus Mundus Joint Doctorate grant (ENC-Network) and ERDF, through Centro 2020 (project no. CENTRO-01-0145-FEDER- 000008:BrainHealth 2020), and through FCT (project nos. POCI- 01-0145-FEDER-007440 and PTDC/NEU-NMC/4154/2016) to RC. HM received funding for this work from the Netherlands Organization for Scientific Research (NWO; VICI grant), ERC StG “BrainSignals,” EU H2020 Framework Program (agreement no. 604102 “Human Brain Project”) and the EU 7th Framework Program (no. EU MSCA-ITN CognitionNet FP7-PEOPLE-2013- ITN 607508). | pt |
dc.language.iso | eng | pt |
dc.publisher | Frontiers Media S.A. | pt |
dc.relation | CENTRO-01-0145-FEDER-000008/BrainHealth2020 | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/NEU/04539/2013/PT | pt |
dc.relation | PTDC/NEU-NMC/4154/2016 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | A2A receptor | pt |
dc.subject | prefrontal cortex (PFC) | pt |
dc.subject | synaptic plasticity | pt |
dc.subject | fast-spiking interneurons | pt |
dc.subject | adenosine | pt |
dc.subject | LTP and LTD | pt |
dc.subject | electrophysiology | pt |
dc.title | Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex | pt |
dc.type | article | - |
degois.publication.firstPage | 133 | pt |
degois.publication.issue | MAR | pt |
degois.publication.title | Frontiers in Pharmacology | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3389/fphar.2018.00133 | pt |
degois.publication.volume | 9 | pt |
dc.date.embargo | 2018-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | CNC. IBILI | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-2550-6422 | - |
crisitem.author.orcid | 0000-0001-7486-5056 | - |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Adenosine A2A receptors control glutamatergic synaptic plasticity in fast spiking interneurons of the prefrontal cortex.pdf | 2.8 MB | Adobe PDF | Ver/Abrir |
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