Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/108266
DC Field | Value | Language |
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dc.contributor.author | Santos, Sónia A. O. | - |
dc.contributor.author | Trindade, Stephanie S. | - |
dc.contributor.author | Oliveira, Catia S. D. | - |
dc.contributor.author | Parreira, Paula | - |
dc.contributor.author | Rosa, Daniela | - |
dc.contributor.author | Duarte, Maria F. | - |
dc.contributor.author | Ferreira, Isabel | - |
dc.contributor.author | Cruz, Maria T. | - |
dc.contributor.author | Rego, Andreia M. | - |
dc.contributor.author | Abreu, Maria H. | - |
dc.contributor.author | Rocha, Sílvia M. | - |
dc.contributor.author | Silvestre, Armando J. D. | - |
dc.date.accessioned | 2023-08-22T08:00:54Z | - |
dc.date.available | 2023-08-22T08:00:54Z | - |
dc.date.issued | 2017-11-01 | - |
dc.identifier.issn | 1660-3397 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/108266 | - |
dc.description.abstract | Macroalgae have been seen as an alternative source of molecules with promising bioactivities to use in the prevention and treatment of current lifestyle diseases. In this vein, the lipophilic fraction of short-term (three weeks) cultivated Bifurcaria bifurcata was characterized in detail by gas chromatography-mass spectrometry (GC-MS). B. bifurcata dichloromethane extract was composed mainly by diterpenes (1892.78 ± 133.97 mg kg-1 dry weight (DW)), followed by fatty acids, both saturated (550.35 ± 15.67 mg kg-1 DW) and unsaturated (397.06 ± 18.44 mg kg-1 DW). Considerable amounts of sterols, namely fucosterol (317.68 ± 26.11 mg kg-1 DW) were also found. In vitro tests demonstrated that the B. bifurcata lipophilic extract show antioxidant, anti-inflammatory and antibacterial activities (against both Gram-positive and Gram-negative bacteria), using low extract concentrations (in the order of µg mL-1). Enhancement of antibiotic activity of drug families of major clinical importance was observed by the use of B. bifurcata extract. This enhancement of antibiotic activity depends on the microbial strain and on the antibiotic. This work represents the first detailed phytochemical study of the lipophilic extract of B. bifurcata and is, therefore, an important contribution for the valorization of B. bifurcata macroalgae, with promising applications in functional foods, nutraceutical, cosmetic and biomedical fields. | pt |
dc.description.sponsorship | The authors wish to thank to FCT-Portugal (Fundação para a Ciência e Tecnologia) and POPH/FSE for the postdoctoral grant to S.A.O.S. (SFRH/BPD/84226/2012), PhD grant to I.F. (SFRH/BD/110717/2015), for CICECO-Aveiro Institute of Materials, POCI-01-0145-FEDER-007679 (FCT Ref. UID/CTM/50011/2013), QOPNA research unit (FCT UID/QUI/00062/2013) financed by national funds through the FCT/MEC and when applicable co-financed by FEDER under the PT2020 Partnership Agreement and CNC financed by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Program: project CENTRO-01-0145-FEDER-000012-HealthyAging2020, the COMPETE 2020—Operational Program for Competitiveness and Internationalization, and the Portuguese national funds via FCT—Fundação para a Ciência e a Tecnologia, I.P.: project POCI-01-0145-FEDER-007440. The work was also supported by FEDER funds through the Operational Program Competitiveness Factors—COMPETE and national funds by FCT under the strategic project UID/NEU/04539/2013. M.F.D. also acknowledges FCT for the financial support under the Project UID/AGR/00115/2013. Part of the work of ALGAplus team was funded by the project SEACOLORS, LIFE13 ENV/ES/000445; | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | SFRH/BPD/84226/2012 | pt |
dc.relation | SFRH/BD/110717/2015 | pt |
dc.relation | info:eu-repo/grantAgreement/UID/NEU/04539/2013 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Bifurcaria bifurcata | pt |
dc.subject | macroalgae | pt |
dc.subject | lipids | pt |
dc.subject | lipophilic compounds | pt |
dc.subject | diterpenes | pt |
dc.subject | antioxidant activity | pt |
dc.subject | anti-inflammatory activity | pt |
dc.subject | antibacterial activity | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Anti-Bacterial Agents | pt |
dc.subject.mesh | Gram-Negative Bacteria | pt |
dc.subject.mesh | Gram-Positive Bacteria | pt |
dc.subject.mesh | Lipids | pt |
dc.subject.mesh | Microbial Sensitivity Tests | pt |
dc.subject.mesh | Plant Extracts | pt |
dc.subject.mesh | Aquatic Organisms | pt |
dc.subject.mesh | Seaweed | pt |
dc.title | Lipophilic Fraction of Cultivated Bifurcaria bifurcata R. Ross: Detailed Composition and In Vitro Prospection of Current Challenging Bioactive Properties | pt |
dc.type | article | - |
degois.publication.firstPage | 340 | pt |
degois.publication.issue | 11 | pt |
degois.publication.title | Marine Drugs | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/md15110340 | pt |
degois.publication.volume | 15 | pt |
dc.date.embargo | 2017-11-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | CNC. IBILI | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-9846-6754 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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Lipophilic-fraction-of-cultivated-Bifurcaria-bifurcata-R-Ross-Detailed-composition-and-in-vitro-prospection-of-current-challenging-bioactive-propertiesMarine-Drugs.pdf | 1.64 MB | Adobe PDF | View/Open |
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