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https://hdl.handle.net/10316/109381
Title: | Endothelial wall thickness, cardiorespiratory fitness and inflammatory markers in obese and non-obese adolescents | Authors: | Silva, Larissa R. Cavaglieri, Cláudia Lopes, Wendell A. Pizzi, Juliana Coelho-e-Silva, Manuel J. C. Leite, Neiva |
Keywords: | obesity; inflammation; atherosclerosis; adolescents; fitness; physical therapy | Issue Date: | 2014 | Publisher: | Elsevier | Serial title, monograph or event: | Brazilian Journal of Physical Therapy | Volume: | 18 | Issue: | 1 | Abstract: | Background: Increased carotid intima-media thickness (c-IMT) is considered a marker of early-onset atherosclerosis and it has been found in obese children and adolescents, but the risk factors associated with this population remain to be elucidated. Objective: To compare and verify the relationship between c-IMT, metabolic profile, inflammatory markers, and cardiorespiratory fitness in obese and non-obese children and adolescents. Method: Thirtyfive obese subjects (19 boys) and 18 non-obese subjects (9 boys), aged 10-16 years, were included. Anthropometry, body composition, blood pressure, maximal oxygen consumption (VO2max), and basal metabolic rate were evaluated. Serum glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), blood lipids, C-reactive protein (CRP), and adiponectin were assessed. c-IMT was measured by ultrasound. Results: The results showed that c-IMT, triglycerides, insulin, HOMA-IR, and CRP values were significantly higher in the obese group than in the non-obese group, and high-density lipoprotein cholesterol (HDL-c), adiponectin, and VO2max values were significantly lower in the obese group than in the non-obese group. The c-IMT was directly correlated with body weight, waist circumference, % body fat, and HOMA-IR and inversely correlated with % free fat mass, HDL-c, and VO2max. Conclusions: Our findings show that c-IMT correlates not only with body composition, lipids, insulin resistance, and inflammation but also with low VO2max values in children and adolescents. | URI: | https://hdl.handle.net/10316/109381 | ISSN: | 1413-3555 | DOI: | 10.1590/S1413-35552012005000133 | Rights: | openAccess |
Appears in Collections: | I&D CIDAF - Artigos em Revistas Internacionais |
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