Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/109429
DC Field | Value | Language |
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dc.contributor.author | Xapelli, Sara Alves | - |
dc.contributor.author | Agasse, Fabienne | - |
dc.contributor.author | Grade, Sofia | - |
dc.contributor.author | Bernardino, Liliana | - |
dc.contributor.author | Ribeiro, Filipa F. | - |
dc.contributor.author | Schitine, Clarissa S. | - |
dc.contributor.author | Heimann, Andrea S. | - |
dc.contributor.author | Ferro, Emer S. | - |
dc.contributor.author | Sebastião, Ana M. | - |
dc.contributor.author | De Melo Reis, Ricardo A. | - |
dc.contributor.author | Malva, João O. | - |
dc.date.accessioned | 2023-10-13T11:28:54Z | - |
dc.date.available | 2023-10-13T11:28:54Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1662-5102 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/109429 | - |
dc.description.abstract | Neural stem cells (NSCs) from the subventricular zone (SVZ) have been indicated as a source of new oligodendrocytes to use in regenerative medicine for myelin pathologies. Indeed, NSCs are multipotent cells that can self-renew and differentiate into all neural cell types of the central nervous system. In normal conditions, SVZ cells are poorly oligodendrogenic, nevertheless their oligodendrogenic potential is boosted following demyelination. Importantly, progressive restriction into the oligodendrocyte fate is specified by extrinsic and intrinsic factors, endocannabinoids being one of these factors. Although a role for endocannabinoids in oligodendrogenesis has already been foreseen, selective agonists and antagonists of cannabinoids receptors produce severe adverse side effects. Herein, we show that hemopressin (Hp), a modulator of CB1 receptors, increased oligodendroglial differentiation in SVZ neural stem/progenitor cell cultures derived from neonatal mice. The original results presented in this work suggest that Hp and derivates may be of potential interest for the development of future strategies to treat demyelinating diseases. | pt |
dc.description.sponsorship | The work was funded by Fundação para a Ciência e a Tecnologia (FCT)–Portugal, projects POCTI/SAU-NEU/68465/2006; PTDC/SAL/NEU/104415/2008; PTDC/SAU-NEU/101783/2008, POCTI/SAU-NEU/110838/2009,by Fundação Calouste Gulbenkian (projectn◦ 96542) and by CAPES-Grices protocol(no 3294-07-2). SX(SFRH/BPD/34870/2007),SG,LB,andFFR were supported by fellowships from FCT.C S was supported by CAPES/FAPERJ. E is supported by CNPq and Pro-Reitoria de Pesquisa da Universidadede SãoPaulo (NAPNA and NAPPS). RAMR is supported by CNPq, FAPERJ ,and INCT-INNT. | pt |
dc.language.iso | eng | pt |
dc.publisher | Frontiers Media S.A. | pt |
dc.relation | POCTI/SAU-NEU/68465/2006 | pt |
dc.relation | PTDC/SAL/NEU/104415/2008 | pt |
dc.relation | TDC/SAU-NEU/101783/2008 | pt |
dc.relation | POCTI/SAU-NEU/110838/2009 | pt |
dc.relation | Fundação Calouste Gulbenkian | pt |
dc.relation | SFRH/BPD/34870/2007 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | oligodendrogenesis | pt |
dc.subject | subventricular zone | pt |
dc.subject | hemopressin | pt |
dc.subject | endocannabinoids | pt |
dc.subject | myelin pathologies | pt |
dc.title | Modulation of subventricular zone oligodendrogenesis: a role for hemopressin? | pt |
dc.type | article | - |
degois.publication.firstPage | 59 | pt |
degois.publication.issue | FEB | pt |
degois.publication.title | Frontiers in Cellular Neuroscience | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3389/fncel.2014.00059 | pt |
degois.publication.volume | 8 | pt |
dc.date.embargo | 2014-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Fundação Calouste Gulbenkian | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-6854-2509 | - |
crisitem.author.orcid | 0000-0002-5438-4447 | - |
Appears in Collections: | I&D IBILI - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Modulation of subventricular zone oligodendrogenesis A role for hemopressin.pdf | 1.06 MB | Adobe PDF | View/Open |
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