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Title: | Slow modulations of high-frequency activity (40-140-Hz) discriminate preictal changes in human focal epilepsy | Authors: | Alvarado-Rojas, C Valderrama, M Fouad-Ahmed, A Feldwisch-Drentrup, H Ihle, M Teixeira, C. A. Sales, F. Schulze-Bonhage, A Adam, C Dourado, A. Charpier, S Navarro, V Le Van Quyen, M |
Issue Date: | 1-Apr-2014 | Publisher: | Springer Nature | Project: | This work was supported by the European Union-FP7 Project EPILEPSIAE (Evolving Platform for Improving Living Expectation of Subjects Suffering from IctAl Events, Grant No 211713) and by the program Investissements d’avenir ANR-10-IAIHU-06, France. C.A.R thanks the Administrative Department for Science, Technology and Innovation (COLCIENCIAS), Colombia, for financial support. V.N. was supported by Contrat d’Interface INSERM. | Serial title, monograph or event: | Scientific Reports | Volume: | 4 | Issue: | 1 | Abstract: | Recent evidence suggests that some seizures are preceded by preictal changes that start from minutes to hours before an ictal event. Nevertheless an adequate statistical evaluation in a large database of continuous multiday recordings is still missing. Here, we investigated the existence of preictal changes in long-term intracranial recordings from 53 patients with intractable partial epilepsy (in total 531 days and 558 clinical seizures). We describe a measure of brain excitability based on the slow modulation of high-frequency gamma activities (40-140 Hz) in ensembles of intracranial contacts. In prospective tests, we found that this index identified preictal changes at levels above chance in 13.2% of the patients (7/53), suggesting that results may be significant for the whole group (p < 0.05). These results provide a demonstration that preictal states can be detected prospectively from EEG data. They advance understanding of the network dynamics leading to seizure and may help develop novel seizure prediction algorithms. | URI: | https://hdl.handle.net/10316/109681 | ISSN: | 2045-2322 | DOI: | 10.1038/srep04545 | Rights: | openAccess |
Appears in Collections: | I&D CISUC - Artigos em Revistas Internacionais |
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