Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/109709
DC Field | Value | Language |
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dc.contributor.author | Parada, Belmiro | - |
dc.contributor.author | Reis, Flávio | - |
dc.contributor.author | Cerejo, Raquel | - |
dc.contributor.author | Garrido, Patrícia | - |
dc.contributor.author | Sereno, José | - |
dc.contributor.author | Xavier-Cunha, Maria | - |
dc.contributor.author | Neto, Paula | - |
dc.contributor.author | Mota, Alfredo | - |
dc.contributor.author | Figueiredo, Arnaldo | - |
dc.contributor.author | Teixeira, Frederico | - |
dc.date.accessioned | 2023-10-23T10:58:48Z | - |
dc.date.available | 2023-10-23T10:58:48Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2314-6133 | pt |
dc.identifier.issn | 2314-6141 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/109709 | - |
dc.description.abstract | Omega-3 (ω-3) fatty acids have been tested on prevention and treatment of several cancer types, but the efficacy on "in vivo" bladder cancer has not been analyzed yet. This study aimed at evaluating the chemopreventive efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) mixture in an animal model of bladder cancer. Forty-four male Wistar rats were divided into 4 groups during a 20-week protocol: control; carcinogen-N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN); ω-3 (DHA + EPA); and ω-3 + BBN. BBN and ω-3 were given during the initial 8 weeks. At week 20 blood and bladder were collected and checked for the presence of urothelium lesions and tumors, markers of inflammation, proliferation, and redox status. Incidence of bladder carcinoma was, control (0%), ω-3 (0%), BBN (65%), and ω-3 + BBN (62.5%). The ω-3 + BBN group had no infiltrative tumors or carcinoma in situ, and tumor volume was significantly reduced compared to the BBN (0.9 ± 0.1 mm(3) versus 112.5 ± 6.4 mm(3)). Also, it showed a reduced MDA/TAS ratio and BBN-induced serum CRP, TGF-β1, and CD31 were prevented. In conclusion, omega-3 fatty acids inhibit the development of premalignant and malignant lesions in a rat model of bladder cancer, which might be due to anti-inflammatory, antioxidant, anti-proliferative, and anti-angiogenic properties. | pt |
dc.language.iso | eng | pt |
dc.publisher | Hindawi | pt |
dc.relation | research grant Associação Portuguesa de Urologia (APU) | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Biomarkers, Tumor | pt |
dc.subject.mesh | Cell Proliferation | pt |
dc.subject.mesh | Chemoprevention | pt |
dc.subject.mesh | Disease Models, Animal | pt |
dc.subject.mesh | Fatty Acids, Omega-3 | pt |
dc.subject.mesh | Immunohistochemistry | pt |
dc.subject.mesh | Inflammation | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Oxidation-Reduction | pt |
dc.subject.mesh | Platelet Endothelial Cell Adhesion Molecule-1 | pt |
dc.subject.mesh | Rats | pt |
dc.subject.mesh | Rats, Wistar | pt |
dc.subject.mesh | Urinary Bladder | pt |
dc.subject.mesh | Urinary Bladder Neoplasms | pt |
dc.title | Omega-3 fatty acids inhibit tumor growth in a rat model of bladder cancer | pt |
dc.type | article | - |
degois.publication.firstPage | 368178 | pt |
degois.publication.lastPage | 11 | pt |
degois.publication.title | BioMed Research International | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1155/2013/368178 | pt |
degois.publication.volume | 2013 | pt |
dc.date.embargo | 2013-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-3401-9554 | - |
crisitem.author.orcid | 0000-0002-7157-0081 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Omega3-fatty-acids-inhibit-tumor-growth-in-a-rat-model-of-bladder-cancerBioMed-Research-International.pdf | 3.5 MB | Adobe PDF | View/Open |
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