Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/109753
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ragàs, Xavier | - |
dc.contributor.author | He, Xin | - |
dc.contributor.author | Agut, Montserrat | - |
dc.contributor.author | Roxo-Rosa, Mónica | - |
dc.contributor.author | Rocha-Gonsalves, António | - |
dc.contributor.author | Serra, Arménio | - |
dc.contributor.author | Nonell, Santi | - |
dc.date.accessioned | 2023-10-25T09:57:07Z | - |
dc.date.available | 2023-10-25T09:57:07Z | - |
dc.date.issued | 2013-02-28 | - |
dc.identifier.issn | 1420-3049 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/109753 | - |
dc.description.abstract | Several families of photosensitizers are currently being scrutinized for antimicrobial photodynamic therapy applications. Differences in physical and photochemical properties can lead to different localization patterns as well as differences in singlet oxygen production and decay when the photosensitizers are taken up by bacterial cells. We have examined the production and fate of singlet oxygen in Escherichia coli upon photosensitization with three structurally-different cationic photosensitizers, namely New Methylene Blue N (NMB), a member of the phenothiazine family, ACS268, a hydrophobic porphyrin with a single cationic alkyl chain, and zinc(II)-tetramethyltetrapyridinoporphyrazinium salt, a phthalocyanine-like photosensitizer with four positive charges on the macrocycle core. The kinetics of singlet oxygen production and decay indicate different localization for the three photosensitizers, whereby NMB appears to localize in an aqueous-like microenvironment, whereas ACS268 localizes in an oxygen-shielded site, highly reactive towards singlet oxygen. The tetracationic zinc(II) tetrapyridinoporphyrazine is extensively aggregated in the bacteria and fails to produce any detectable singlet oxygen. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | Spanish Ministerio de Economía y Competitividad (CTQ2007-67763-C03-01/ BQU and CTQ2010-20870-C03-01) | pt |
dc.relation | Chymiotechnon, Portugal | pt |
dc.relation | Generalitat de Catalunya and Fons Social Europeu predoctoral fellowship | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | antimicrobial photodynamic therapy | pt |
dc.subject | cationic photosensitizers | pt |
dc.subject | E. coli | pt |
dc.subject | kinetics | pt |
dc.subject | photodynamic inactivation | pt |
dc.subject | singlet oxygen | pt |
dc.subject | time-resolved near-IR spectroscopy | pt |
dc.subject.mesh | Anti-Infective Agents | pt |
dc.subject.mesh | Escherichia coli | pt |
dc.subject.mesh | Indoles | pt |
dc.subject.mesh | Isoindoles | pt |
dc.subject.mesh | Kinetics | pt |
dc.subject.mesh | Photosensitizing Agents | pt |
dc.subject.mesh | Porphyrins | pt |
dc.subject.mesh | Singlet Oxygen | pt |
dc.subject.mesh | Photochemotherapy | pt |
dc.title | Singlet oxygen in antimicrobial photodynamic therapy: photosensitizer-dependent production and decay in E. coli | pt |
dc.type | article | - |
degois.publication.firstPage | 2712 | pt |
degois.publication.lastPage | 2725 | pt |
degois.publication.issue | 3 | pt |
degois.publication.title | Molecules | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/molecules18032712 | pt |
degois.publication.volume | 18 | pt |
dc.date.embargo | 2013-02-28 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CEMMPRE - Centre for Mechanical Engineering, Materials and Processes | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0001-9987-7301 | - |
crisitem.author.orcid | 0000-0001-8664-2757 | - |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Singlet-oxygen-in-antimicrobial-photodynamic-therapy-Photosensitizer-dependent-production-and-decay-in-E-coliMolecules.pdf | 505.64 kB | Adobe PDF | View/Open |
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