Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/110203
DC Field | Value | Language |
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dc.contributor.author | Ferreira, Liliana | - |
dc.contributor.author | Teixeira-Lemos, Edite | - |
dc.contributor.author | Pinto, Filipa | - |
dc.contributor.author | Parada, Belmiro | - |
dc.contributor.author | Mega, Cristina | - |
dc.contributor.author | Vala, Helena | - |
dc.contributor.author | Pinto, Rui | - |
dc.contributor.author | Garrido, Patrícia | - |
dc.contributor.author | Sereno, José | - |
dc.contributor.author | Fernandes, Rosa | - |
dc.contributor.author | Santos, Paulo | - |
dc.contributor.author | Velada, Isabel | - |
dc.contributor.author | Melo, Andreia | - |
dc.contributor.author | Nunes, Sara | - |
dc.contributor.author | Teixeira, Frederico | - |
dc.contributor.author | Reis, Flávio | - |
dc.date.accessioned | 2023-11-17T10:59:24Z | - |
dc.date.available | 2023-11-17T10:59:24Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0962-9351 | pt |
dc.identifier.issn | 1466-1861 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/110203 | - |
dc.description.abstract | The purpose of this paper is to evaluate the chronic effect of sitagliptin on metabolic profile, inflammation, and redox status in the Zucker Diabetic Fatty (ZDF) rat, an animal model of obese type 2 diabetes. Diabetic and obese ZDF (fa/fa) rats and their controls (ZDF +/+) were treated during 6 weeks with vehicle (control) and sitagliptin (10 mg/kg/bw). Glucose, HbA1c, insulin, Total-c, TGs, IL-1beta, TNF-alpha, CRPhs, and adiponectin were assessed in serum and MDA and TAS in serum, pancreas, and heart. Pancreatic histology was also evaluated. Sitagliptin in diabetic rats promoted a decrease in glucose, HbA1c, Total-c, and TGs accompanied by a partial prevention of insulinopenia, together, with a decrease in CRPhs and IL-1beta. Sitagliptin also showed a positive impact on lipid peroxidation and hypertension prevention. In conclusion, chronic sitagliptin treatment corrected the glycaemic dysmetabolism, hypertriglyceridaemia, inflammation, and hypertension, reduced the severity of the histopathological lesions of pancreatic endocrine and exocrine tissues, together with a favourable redox status, which might be a further advantage in the management of diabetes and its proatherogenic comorbidities. | pt |
dc.language.iso | eng | pt |
dc.publisher | Hindawi | pt |
dc.relation | Merck Sharp & Dohme Foundation, Portugal. | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Blood Glucose | pt |
dc.subject.mesh | Blood Pressure | pt |
dc.subject.mesh | Body Weight | pt |
dc.subject.mesh | C-Reactive Protein | pt |
dc.subject.mesh | Diabetes Mellitus, Type 2 | pt |
dc.subject.mesh | Dipeptidyl-Peptidase IV Inhibitors | pt |
dc.subject.mesh | Disease Models, Animal | pt |
dc.subject.mesh | Glycated Hemoglobin | pt |
dc.subject.mesh | Insulin | pt |
dc.subject.mesh | Insulin Resistance | pt |
dc.subject.mesh | Interleukin-1beta | pt |
dc.subject.mesh | Lipids | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Oxidative Stress | pt |
dc.subject.mesh | Pancreas | pt |
dc.subject.mesh | Pyrazines | pt |
dc.subject.mesh | Rats | pt |
dc.subject.mesh | Sitagliptin Phosphate | pt |
dc.subject.mesh | Triazoles | pt |
dc.title | Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat) | pt |
dc.type | article | - |
degois.publication.firstPage | 592760 | pt |
degois.publication.lastPage | 11 | pt |
degois.publication.title | Mediators of Inflammation | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1155/2010/592760 | pt |
degois.publication.volume | 2010 | pt |
dc.date.embargo | 2010-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0002-6346-8319 | - |
crisitem.author.orcid | 0000-0001-7828-2296 | - |
crisitem.author.orcid | 0000-0002-2601-0923 | - |
crisitem.author.orcid | 0000-0003-3401-9554 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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Effects-of-sitagliptin-treatment-on-dysmetabolism-inflammation-and-oxidative-stress-in-an-animal-model-of-type-2-diabetes-ZDF-ratMediators-of-Inflammation.pdf | 3.93 MB | Adobe PDF | View/Open |
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