Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/111762
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sousa, Adelaide | - |
dc.contributor.author | Azevedo, Rui | - |
dc.contributor.author | Costa, Vera Marisa | - |
dc.contributor.author | Oliveira, Sara | - |
dc.contributor.author | Preguiça, Inês | - |
dc.contributor.author | Viana, Sofia | - |
dc.contributor.author | Reis, Flávio | - |
dc.contributor.author | Almeida, Agostinho | - |
dc.contributor.author | Matafome, Paulo N. | - |
dc.contributor.author | Dias-Pereira, Patrícia | - |
dc.contributor.author | Carvalho, Félix | - |
dc.contributor.author | Fernandes, Eduarda | - |
dc.contributor.author | Freitas, Marisa da Silva | - |
dc.date.accessioned | 2024-01-09T11:28:47Z | - |
dc.date.available | 2024-01-09T11:28:47Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 0340-5761 | - |
dc.identifier.issn | 1432-0738 | - |
dc.identifier.uri | https://hdl.handle.net/10316/111762 | - |
dc.description.abstract | Silver nanoparticles (AgNP) are among the most widely commercialized nanomaterials globally, with applications in medicine and the food industry. Consequently, the increased use of AgNP in the food industry has led to an unavoidable rise in human exposure to these nanoparticles. Their widespread use raises concerns about potential hazards to human health, specifically their intestinal pro-inflammatory effects. Thus, the main objective of this study was to evaluate the biological effects of two subacute doses of 5 nm polyvinylpyrrolidone (PVP)-AgNP in C57BL/6J mice. One mg/kg body weight or 10 mg/kg bw was provided once a day for 14 days, using a new technology (HaPILLness) that allows voluntary, stress-free, and accurate oral dosing. It was observed that after oral ingestion, while AgNP is biodistributed throughout the entire organism, most of the ingested dose is excreted in the feces. The passage and accumulation of AgNP throughout the intestine instigated a prominent inflammatory response, marked by significant histological, vascular, and cellular transformations. This response was driven by the activation of the nuclear factor-кB (NF-кB) inflammatory pathway, ultimately leading to the generation of multiple cytokines and chemokines. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | UIBD/50006/2020 | pt |
dc.relation | UIDP/50006/2020 | pt |
dc.relation | PTDC/ NAN-MAT/29248/2017 | pt |
dc.relation | POCI‑01‑0145‑FEDER‑029248 | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | info:eu-repo/grantAgreement/UIDP/04539/2020 | pt |
dc.relation | LA/P/0058/2020 | pt |
dc.relation | SFRH/BD/150656/2020 | pt |
dc.relation | 2020.04126.CEECIND | pt |
dc.relation | LA/P/0008/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Oral intake | pt |
dc.subject | Biodistribution | pt |
dc.subject | Subacute toxicity | pt |
dc.subject | Intestinal inflammation | pt |
dc.subject | NF-кB inflammatory pathway | pt |
dc.subject | Cytokines and chemokines | pt |
dc.title | Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice | pt |
dc.type | article | pt |
degois.publication.firstPage | 2643 | pt |
degois.publication.lastPage | 2657 | pt |
degois.publication.issue | 10 | pt |
degois.publication.title | Archives of Toxicology | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1007/s00204-023-03558-5 | - |
degois.publication.volume | 97 | pt |
dc.date.embargo | 2023-10-01 | * |
dc.identifier.pmid | 37594589 | - |
uc.date.periodoEmbargo | 0 | pt |
dc.identifier.eissn | 1432-0738 | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Associated Laboratory for Green Chemistry - Clean Technologies and Processes | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - Associate Laboratory | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-1316-1319 | - |
crisitem.author.orcid | 0000-0003-3401-9554 | - |
crisitem.author.orcid | 0000-0002-3422-290X | - |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Biodistribution-and-intestinal-inflammatory-response-following-voluntary-oral-intake-of-silver-nanoparticles-by-C57BL6J-miceArchives-of-Toxicology.pdf | 11.22 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
3
checked on Sep 23, 2024
WEB OF SCIENCETM
Citations
2
checked on Sep 2, 2024
Page view(s)
78
checked on Oct 2, 2024
Download(s)
30
checked on Oct 2, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License