Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/112366
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Iglesias, Bernardo Almeida | - |
dc.contributor.author | Peranzoni, Níckolas Pippi | - |
dc.contributor.author | Faria, Sophia Iwersen | - |
dc.contributor.author | Trentin, Luana Belo | - |
dc.contributor.author | Schuch, André Passaglia | - |
dc.contributor.author | Chaves, Otávio Augusto | - |
dc.contributor.author | Bertoloni, Renan Ribeiro | - |
dc.contributor.author | Nikolaou, Sofia | - |
dc.contributor.author | de Oliveira, Kleber Thiago | - |
dc.date.accessioned | 2024-01-30T11:20:03Z | - |
dc.date.available | 2024-01-30T11:20:03Z | - |
dc.date.issued | 2023-07-05 | - |
dc.identifier.issn | 1420-3049 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/112366 | - |
dc.description.abstract | We report the DNA-binding properties of three porphyrins with peripheral thienyl substituents (TThPor, PdTThPor and PtTThPor). The binding capacity of each porphyrin with DNA was determined by UV-Vis and steady-state fluorescence emission spectroscopy combined with molecular docking calculations. The results suggest that the interaction of these compounds probably occurs via secondary interactions via external grooves (minor grooves) around the DNA macromolecule. Moreover, porphyrins containing peripheral Pd(II) or Pt(II) complexes (PdTThPor and PtTThPor) were able to promote photo-damage in the DNA. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | UIDB/00313/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | porphyrins | pt |
dc.subject | thienyl-porphyrins | pt |
dc.subject | Pt(II) and Pd(II) complexes | pt |
dc.subject | DNA | pt |
dc.subject | photobiology | pt |
dc.subject.mesh | Molecular Docking Simulation | pt |
dc.subject.mesh | Spectrometry, Fluorescence | pt |
dc.subject.mesh | DNA | pt |
dc.subject.mesh | Porphyrins | pt |
dc.title | DNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes | pt |
dc.type | article | - |
degois.publication.firstPage | 5217 | pt |
degois.publication.issue | 13 | pt |
degois.publication.title | Molecules | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/molecules28135217 | pt |
degois.publication.volume | 28 | pt |
dc.date.embargo | 2023-07-05 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Coimbra Chemistry Center | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0001-6211-7659 | - |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais I&D CQC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
DNAInteractive-and-Damage-Study-with-mesoTetra2thienylporphyrins-Coordinated-with-Polypyridyl-PdII-and-PtII-ComplexesMolecules.pdf | 2.25 MB | Adobe PDF | View/Open |
Page view(s)
89
checked on Oct 2, 2024
Download(s)
36
checked on Oct 2, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License