Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113184
DC Field | Value | Language |
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dc.contributor.author | Branco, Ana | - |
dc.contributor.author | Moniz, Inês | - |
dc.contributor.author | Santos, João Ramalho | - |
dc.date.accessioned | 2024-02-08T10:36:16Z | - |
dc.date.available | 2024-02-08T10:36:16Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 01719335 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/113184 | - |
dc.description.abstract | Organismal aging is impacted by the deterioration of tissue turnover mechanisms due, in part, to the decline in stem cell function. This decline can be related to mitochondrial dysfunction and underlying energetic defects that, in concert, help drive biological aging. Thus, mitochondria have been described as a potential interventional target to hinder the loss of stem cell robustness, and subsequently, decrease tissue turnover decline and age-associated pathologies. In this review, we focused our analysis on the most recent literature on mitochondria and stem cell aging and discuss the potential benefits of targeting mitochondria in preventing stem cell dysfunction and thus influencing aging. | pt |
dc.language.iso | eng | pt |
dc.publisher | Elsevier | pt |
dc.relation | A.F.B. and I.M. were funded by Fundaç˜ao para a Ciˆencia e Tecnologia (FCT) Portugal under a CEEC contract (CEECIND/00860/2018) and a PhD fellowship (2022.10535.BD), respectively. Additional funding was provided by the STEM@REST Project (CENTRO-01-0145-FEDER- 028871) and by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme: project CENTRO-01-0145-FEDER-000012-HealthyAging2020, the COMPETE 2020—Operational Programme for Competitiveness and Internationalisation, and the Portuguese national funds via FCT—Fundaç˜ao para a Ciˆencia e a Tecnologia, I.P. through the Strategic Projects POCI-01- 0145-FEDER-007440 and UID/NEU/04539/2020. | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.subject | Mesenchymal stem cell | pt |
dc.subject | Aging | pt |
dc.subject | Mitochondria | pt |
dc.subject.mesh | Stem Cells | pt |
dc.subject.mesh | Cellular Senescence | pt |
dc.subject.mesh | Mitochondria | pt |
dc.title | Mitochondria as biological targets for stem cell and organismal senescence | pt |
dc.type | article | - |
degois.publication.firstPage | 151289 | pt |
degois.publication.issue | 2 | pt |
degois.publication.title | European Journal of Cell Biology | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.ejcb.2023.151289 | pt |
degois.publication.volume | 102 | pt |
dc.date.embargo | 2023-06-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-0415-3560 | - |
crisitem.author.orcid | 0000-0002-0381-4101 | - |
crisitem.author.orcid | 0000-0002-1172-4018 | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Mitochondria as biological targets for stem cell and organismal senescence.pdf | 1.19 MB | Adobe PDF | View/Open |
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