Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/113358
Title: Thermo‐Responsive Microemulsions Containing Deep Eutectic‐Based Antibiotic Formulations for Improved Treatment of Resistant Bacterial Ocular Infections
Authors: Pedro, Sónia N.
Gomes, Ana T. P. C.
Vilela, Carla
Vitorino, Carla 
Fernandes, Rosa 
Almeida, Adelaide 
Amaral, Maria Helena
Freire, Mara G. 
Silvestre, Armando J. D. 
Freire, Carmen S. R.
Keywords: antibiotics; chloramphenicol; deep eutectic solvents; drug delivery; microemulsions; thermo-responsive systems
Issue Date: 2023
Publisher: Wiley-Blackwell
Project: UIDB/50011/2020 
UIDP/50011/2020 
LA/P/0006/2020 
UIDP/50017/2020 
UIDB/50017/2020 
LA/P/0094/2020 
UIDB/04539/2020 
POCI-01-0145-FEDER-007440 
info:eu-repo/grantAgreement/UIDP/04539/2020 
CENTRO-01-0145-FEDER-000008 
UID/QUI/00313/2020 
SFRH/BD/132584/2017 
CEECIND/00263/2018 
2021.01571.CEECIND 
CEECIND/00464/2017 
Serial title, monograph or event: Advanced Therapeutics
Volume: 6
Issue: 5
Abstract: The rise of antibiotic resistant strains, as methicillin-resistant Staphylococcus aureus (MRSA), challenges the current treatment of infections. In the case of ocular infections, antibiotic eye drops are commonly prescribed. However, their efficacy is usually compromised by the low viscosity of these formulations and the eye drainage. To overcome these drawbacks, deep eutectic solvent (DES)-based microemulsions with thermo-responsive character, that increase their viscosity upon contact with the eye have been developed. Using betaine-based DES aqueous solutions, it is possible to increase up to 140-fold the water solubility of the antibiotic chloramphenicol, typically used in ocular infections. The DES solutions containing the antibiotic are applied as water phases in water-in-oil-in-water (w/o/w) microemulsions, being stable up to 3 months. Furthermore, a sustained-release and a higher permeation of the antibiotic through the cornea than that of commercialized eye drops is achieved, while presenting comparable cytotoxicity profiles (cell viabilities > 88%). Higher antimicrobial activity and faster action of the antibiotic in case of infection with MRSA is observed compared to the commercialized formulations (7 log10 of inactivation in 48 h vs 72 h). Overall, these microemulsions comprising DES are a promising strategy to achieve higher antibiotic effectiveness in the treatment of resistant bacterial infections.
URI: https://hdl.handle.net/10316/113358
ISSN: 2366-3987
2366-3987
DOI: 10.1002/adtp.202200235
Rights: openAccess
Appears in Collections:I&D ICBR - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
I&D CQC - Artigos em Revistas Internacionais
FCTUC Química - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais

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This item is licensed under a Creative Commons License Creative Commons