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Title: | A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases | Authors: | Fernandes, Tânia Domingues, M. Rosário M. Moreira, Paula I. Pereira, Cláudia F. |
Keywords: | neurodegenerative disorders; ER–mitochondria contacts; lipid storage; lipophagy; energy production | Issue Date: | 8-Mar-2023 | Publisher: | MDPI | Project: | CENTRO-01-0145-FEDER-000012 POCI-01- 0145-FEDER-028214 PTDC/MED-NEU/28214/2017 POCI-01-0145-FEDER-029369 PTDC/MEDFAR/29369/2017 UIDB/04539/2020 info:eu-repo/grantAgreement/UIDP/04539/2020 EXPL/MED-FSL/0033/2021 UIDP/50017/2020 UIDB/50017/2020 LA/P/0094/2020 SFRH/BD/148801/2019 |
Serial title, monograph or event: | Biology | Volume: | 12 | Issue: | 3 | Abstract: | Mitochondria interact with the endoplasmic reticulum (ER) through contacts called mitochondria-associated membranes (MAMs), which control several processes, such as the ER stress response, mitochondrial and ER dynamics, inflammation, apoptosis, and autophagy. MAMs represent an important platform for transport of non-vesicular phospholipids and cholesterol. Therefore, this region is highly enriched in proteins involved in lipid metabolism, including the enzymes that catalyze esterification of cholesterol into cholesteryl esters (CE) and synthesis of triacylglycerols (TAG) from fatty acids (FAs), which are then stored in lipid droplets (LDs). LDs, through contact with other organelles, prevent the toxic consequences of accumulation of unesterified (free) lipids, including lipotoxicity and oxidative stress, and serve as lipid reservoirs that can be used under multiple metabolic and physiological conditions. The LDs break down by autophagy releases of stored lipids for energy production and synthesis of membrane components and other macromolecules. Pathological lipid deposition and autophagy disruption have both been reported to occur in several neurodegenerative diseases, supporting that lipid metabolism alterations are major players in neurodegeneration. In this review, we discuss the current understanding of MAMs structure and function, focusing on their roles in lipid metabolism and the importance of autophagy in LDs metabolism, as well as the changes that occur in neurogenerative diseases. | URI: | https://hdl.handle.net/10316/113780 | ISSN: | 2079-7737 | DOI: | 10.3390/biology12030414 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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