Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/113853
Título: | Randomized clinical study of injectable dextrin-based hydrogel as a carrier of a synthetic bone substitute | Autor: | Machado, Alexandra Pereira, Isabel Costa, Filomena Brandão, Ana Pereira, José Eduardo Maurício, Ana Colette Santos, José Domingos Amaro, Inês Falacho, Rui I. Coelho, Rui Cruz, Nuno Gama, Miguel |
Palavras-chave: | Synthetic bone; Dextrin; Injectable hydrogel; Alveolar preservation | Data: | Mar-2023 | Editora: | Springer Nature | Projeto: | UID/BIO/04469 POCI-01–0145- FEDER-006684 NORTE-01–0145- FEDER-000004 UIDB/CVT/00772/2020 SFRH/ BD/132000/2017 |
Título da revista, periódico, livro ou evento: | Clinical Oral Investigations | Volume: | 27 | Número: | 3 | Resumo: | Objectives This study aimed to improve the performance and mode of administration of a glass-reinforced hydroxyapatite synthetic bone substitute, Bonelike by Biosckin® (BL®), by association with a dextrin-based hydrogel, DEXGEL, to achieve an injectable and moldable device named DEXGEL Bone. Methods Twelve participants requiring pre-molar tooth extraction and implant placement were enrolled in this study. BL® granules (250–500 μm) were administered to 6 randomized participants whereas the other 6 received DEXGEL Bone. After 6 months, a bone biopsy of the grafted area was collected for histological and histomorphometric evaluation, prior to implant placement. The performance of DEXGEL Bone and BL® treatments on alveolar preservation were further analyzed by computed tomography and Hounsfield density analysis. Primary implant stability was analyzed by implant stability coefficient technique. Results The healing of defects was free of any local or systemic complications. Both treatments showed good osseointegration with no signs of adverse reaction. DEXGEL Bone exhibited increased granule resorption (p = 0.029) accompanied by a tendency for more new bone ingrowth (although not statistically significant) compared to the BL® group. The addition of DEXGEL to BL® granules did not compromise bone volume or density, being even beneficial for implant primary stability (p = 0.017). Conclusions The hydrogel-reinforced biomaterial exhibited an easier handling, a better defect filling, and benefits in implant stability. Clinical relevance This study validates DEXGEL Bone safety and performance as an injectable carrier of granular bone substitutes for alveolar ridge preservation. Trial registration European Databank on Medical Devices (EUDAMED) No. CIV-PT-18–01-02,705; Registo Nacional de Estudos Clínicos, RNEC, No. 30122. | URI: | https://hdl.handle.net/10316/113853 | ISSN: | 1436-3771 | DOI: | 10.1007/s00784-023-04868-9 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Randomized-clinical-study-of-injectable-dextrinbased-hydrogel-as-a-carrier-of-a-synthetic-bone-substituteClinical-Oral-Investigations.pdf | 4.61 MB | Adobe PDF | Ver/Abrir |
Visualizações de página
112
Visto em 2/out/2024
Downloads
57
Visto em 2/out/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons