Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/116126
Title: Cellular reprogramming as a tool to model human aging in a dish
Authors: Pitrez, Patrícia R. 
Monteiro, Luís M. 
Borgogno, Oliver
Nissan, Xavier
Mertens, Jerome
Ferreira, Lino 
Issue Date: 28-Feb-2024
Publisher: Nature Research
Project: info:eu-repo/grantAgreement/FCT/PTDC/BTM-SAL/5174/2020 
info:eu-repo/grantAgreement/HE/101087071/CHAngeing 
info:eu-repo/grantAgreement/FCT/2022.07615.PTDC 
info:eu-repo/grantAgreement/H2020/952266/RESETageing 
info:eu-repo/grantAgreement/HE/101129812/REGENERAR 
info:eu-repo/grantAgreement/HE/101080229/DREAMS 
metadata.degois.publication.title: Nature Communications
metadata.degois.publication.volume: 15
metadata.degois.publication.issue: 1
Abstract: The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.
URI: https://hdl.handle.net/10316/116126
ISSN: 2041-1723
DOI: 10.1038/s41467-024-46004-5
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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