Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/25537
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rocha, Nuno | - |
dc.contributor.author | Mendes, Joana | - |
dc.contributor.author | Durães, Luísa | - |
dc.contributor.author | Maleki, Hajar | - |
dc.contributor.author | Portugal, António | - |
dc.contributor.author | Geraldes, C. F. G. C. | - |
dc.contributor.author | Serra, Arménio | - |
dc.contributor.author | Coelho, Jorge | - |
dc.date.accessioned | 2014-04-11T10:16:19Z | - |
dc.date.available | 2014-04-11T10:16:19Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://hdl.handle.net/10316/25537 | - |
dc.description.abstract | This work reports an efficient method for the preparation of aqueous dispersions of superparamagnetic iron oxide nanoparticles (SPIONs), involving the use of an amphiphilic block copolymer, poly(ethylene glycol)- block-poly(4-vinyl pyridine) (mPEG-b-P4VP). The iron oxide nanoparticles are easily and efficiently dispersed due to the strong direct interaction of the hydrophobic P4VP segments, through complexation with pyridine units of the copolymer. Well-defined block copolymers, having different compositions and molecular weights, were prepared by atom transfer radical polymerization (ATRP). The aqueous selfassembly behavior of each system has been compared based on the method of preparation. The results revealed that the addition of ionic species has a significant effect on the size and type of formed nanostructures, the magnitude of which is dependent on the block copolymers' molecular design. When similar self-assembly strategies were used in the presence of SPIONs, the same type of nanostructures was formed. The hybrid SPION nanoaggregates were investigated using NMR relaxometric techniques, whereby high r2/r1 relaxivity ratios were achieved, making these materials potentially efficient T2- weighted MRI contrast agents. | por |
dc.description.sponsorship | This work was financially supported by Fundação para a Ciência e a Tecnologia (Portugal), project Nanohybrid (PTDC/EQU-EPR/ 114354/2009) and project PEst-C/SAU/LA0001/2011, by Rede Nacional de RMN (REDE/1517/RMN/2005) with the acquisition of the Bruker Avance III 400 MHz NMR spectrometer in Coimbra (FEDER) and by the EU COST TD1004 Action “Theragnostics Imaging and Therapy”. Nuno Rocha acknowledges FCT-MCTES for his postdoctoral scholarship (SFRH/BPD/86352/2012). | por |
dc.language.iso | eng | por |
dc.publisher | The Royal Society of Chemistry | por |
dc.rights | openAccess | por |
dc.title | Poly(ethylene glycol)-block-poly(4-vinyl pyridine) as a versatile block copolymer to prepare nanoaggregates of superparamagnetic iron oxide nanoparticles | por |
dc.type | article | por |
degois.publication.firstPage | 1565 | por |
degois.publication.lastPage | 1575 | por |
degois.publication.issue | 11 | por |
degois.publication.title | Journal of Materials Chemistry B | por |
dc.relation.publisherversion | http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/c3tb21454k#!divAbstract | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1039/c3tb21454k | - |
degois.publication.volume | 2 | por |
uc.controloAutoridade | Sim | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CEMMPRE - Centre for Mechanical Engineering, Materials and Processes | - |
crisitem.author.researchunit | CIEPQPF – Chemical Process Engineering and Forest Products Research Centre | - |
crisitem.author.researchunit | CFE - Centre for Functional Ecology - Science for People & the Planet | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CEMMPRE - Centre for Mechanical Engineering, Materials and Processes | - |
crisitem.author.researchunit | CEMMPRE - Centre for Mechanical Engineering, Materials and Processes | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-7779-2558 | - |
crisitem.author.orcid | 0000-0003-3336-2449 | - |
crisitem.author.orcid | 0000-0003-1748-6345 | - |
crisitem.author.orcid | 0000-0002-0837-8329 | - |
crisitem.author.orcid | 0000-0001-8664-2757 | - |
crisitem.author.orcid | 0000-0001-9351-1704 | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais I&D CERES - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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c3tb21454k.pdf | 1.01 MB | Adobe PDF | View/Open |
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