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https://hdl.handle.net/10316/27927
Title: | Multi-residue and multi-class method for the determination of antibiotics in bovine muscle by ultra-high-performance liquid chromatography tandem mass spectrometry | Authors: | Freitas, Andreia Barbosa, Jorge Ramos, Fernando |
Keywords: | Antibiotics; Multi-class; Multi-detection; UHPLC–MS/MS; Muscle; Validation | Issue Date: | Sep-2014 | Publisher: | Elsevier | Citation: | FREITAS, Andreia; BARBOSA, Jorge; RAMOS, Fernando - Multi-residue and multi-class method for the determination of antibiotics in bovine muscle by ultra-high-performance liquid chromatography tandem mass spectrometry. "Meat Science". ISSN 0309-1740. Vol. 98 Nº. 1 (2014) p. 58–64 | metadata.degois.publication.title: | Meat Science | metadata.degois.publication.volume: | 98 | metadata.degois.publication.issue: | 1 | Abstract: | A multi-residue quantitative screening method covering 41 antibiotics from 7 different families, by ultra-high-performance–liquid-chromatography tandem mass spectrometry (UHPLC–MS/MS), is described. Sulfonamides, trimethoprim, tetracyclines, macrolides, quinolones, penicillins and chloramphenicol are simultaneously detected after a simple sample preparation of bovine muscle optimized to achieve the best recovery for all compounds. A simple sample treatment was developed consisting in an extraction with a mixture of acetonitrile and ethylenediaminetetraacetic acid (EDTA), followed by a defatting step with n-hexane. The methodology was validated, in accordance with Decision 2002/657/EC by evaluating the required parameters: decision limit (CCα), detection capability (CCβ), specificity, repeatability and reproducibility. Precision in terms of relative standard deviation was under 20% for all compounds and the recoveries between 91% and 119%. CCα and CCβ were determined according the maximum residue limit (MRL) or the minimum required performance limit (MRPL), when required. | URI: | https://hdl.handle.net/10316/27927 | ISSN: | 0309-1740 | DOI: | 10.1016/j.meatsci.2014.04.003 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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Multi-residue and multi-class method for the determination.pdf | 323.66 kB | Adobe PDF | View/Open |
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