Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/28266
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Areia, Ana | - |
dc.contributor.author | Vale-Pereira, Sofia | - |
dc.contributor.author | Alves, Vera | - |
dc.contributor.author | Rodrigues-Santos, Paulo | - |
dc.contributor.author | Moura, Paulo | - |
dc.contributor.author | Mota-Pinto, Anabela | - |
dc.date.accessioned | 2015-02-19T16:29:46Z | - |
dc.date.available | 2015-02-19T16:29:46Z | - |
dc.date.issued | 2015-02-02 | - |
dc.identifier.uri | https://hdl.handle.net/10316/28266 | - |
dc.description.abstract | Objective - To provide evidence of the existence of membrane progesterone receptor alpha (mPRa) on regulatory T cells (Treg) in peripheral blood during pregnancy, postulating a possible explanation for the effect of progesterone on preterm birth. Design Cross-sectional study. Setting - Tertiary Obstetric Department in a University Hospital. Population - Healthy pregnant women. Methods - Treg cells from peripheral blood samples were studied by flow cytometry using multiple monoclonal antibody expression. Main outcome measures - Evaluate the number and percentage of CD4+CD25highCD127low, the number and percentage of Treg cells among the total CD4+ T cells, and the percentage and mean fluorescence intensity (MFI) of mPRa in that population, using several gating strategies. Results - 43 peripheral blood samples were collected from healthy women during pregnancy, whose median gestational age was 28.7 7.1 (16–40) weeks. The percentage of CD4+ in the total lymphocytes was 43% (32–51) and the percentage of CD4+CD25highCD127low was 4.8% (1.6–5.9), with only 45% (16–72) of those cells expressing the intracellular marker FoxP3 (Treg cell pool). We confirmed the existence of mPRa in that specific population because 8.0% (2.02–33) of the Treg cells were marked with the specific monoclonal antibody, with an mPRa+ MFI of 719 (590–1471). Conclusions - This research shows that Treg cells express mPRa during pregnancy, which might play an important role in immune modulation by progesterone. | por |
dc.language.iso | eng | por |
dc.publisher | Royal College of Obstetricians and Gynaecologists | por |
dc.rights | openAccess | por |
dc.subject | Pregnancy | por |
dc.subject | Progesterone receptor | por |
dc.subject | T regulatory cells | por |
dc.title | Membrane progesterone receptors in human regulatory T cells: a reality in pregnancy | por |
dc.type | article | por |
degois.publication.title | BJOG: An International Journal of Obstetrics & Gynaecology | por |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.13294/abstract | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1111/1471-0528.13294 | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-2371-8907 | - |
crisitem.author.orcid | 0000-0002-0820-9568 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Membrane progesterone receptors(BJOG15).pdf | 217.14 kB | Adobe PDF | View/Open |
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