Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/45150
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Fiuza, S. M. | - |
dc.contributor.author | Gomes, C. | - |
dc.contributor.author | Teixeira, L. J. | - |
dc.contributor.author | Girão da Cruz, M. T. | - |
dc.contributor.author | Cordeiro, M. N. D. S. | - |
dc.contributor.author | Milhazes, N. | - |
dc.contributor.author | Borges, F. | - |
dc.contributor.author | Marques, M. P. M. | - |
dc.date.accessioned | 2017-12-15T18:54:10Z | - |
dc.date.available | 2017-12-15T18:54:10Z | - |
dc.date.issued | 2004 | - |
dc.identifier.uri | https://hdl.handle.net/10316/45150 | - |
dc.description.abstract | The antiproliferative and cytotoxic properties of polyphenolic acid derivatives, structurally related with the natural models caffeic and gallic acids, have been tested in human cervix adenocarcinoma cells (HeLa). Simultaneous structural information was obtained for these compounds through theoretical ab initio methods. This study was conducted for the following esters: methyl caffeate (MC, 1), propyl caffeate (PC, 2), octyl caffeate (OC, 3), methyl gallate (MG, 4), propyl gallate (PG, 5) and octyl gallate (OG, 6). A significant growth-inhibition effect was assessed for some of these compounds, clearly dependent on their structural characteristics. Marked structure-activity relationships (SARs)--namely the number of hydroxyl ring substituents--were found to rule the biological effect of such systems. | por |
dc.language.iso | eng | por |
dc.rights | openAccess | por |
dc.subject | Antineoplastic Agents | por |
dc.subject | Caffeic Acids | por |
dc.subject | Cell Line | por |
dc.subject | Cell Survival | por |
dc.subject | Drug Screening Assays, Antitumor | por |
dc.subject | Esters | por |
dc.subject | Gallic Acid | por |
dc.subject | Humans | por |
dc.subject | Hydroxybenzoates | por |
dc.subject | Inhibitory Concentration 50 | por |
dc.subject | Methylation | por |
dc.subject | Molecular Structure | por |
dc.subject | Structure-Activity Relationship | por |
dc.title | Phenolic acid derivatives with potential anticancer properties––a structure–activity relationship study. Part 1: Methyl, propyl and octyl esters of caffeic and gallic acids | por |
dc.type | article | - |
degois.publication.firstPage | 3581 | por |
degois.publication.lastPage | 3589 | por |
degois.publication.issue | 13 | por |
degois.publication.title | Bioorganic & Medicinal Chemistry | por |
dc.peerreviewed | yes | por |
dc.identifier.doi | 10.1016/j.bmc.2004.04.026 | por |
dc.identifier.doi | 10.1016/j.bmc.2004.04.026 | - |
degois.publication.volume | 12 | por |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | QFM-UC – Molecular Physical-Chemistry R&D Unit | - |
crisitem.author.orcid | 0000-0002-5171-0454 | - |
crisitem.author.orcid | 0000-0002-8391-0055 | - |
Aparece nas coleções: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
BMC_04_12.pdf | 490.39 kB | Adobe PDF | Ver/Abrir |
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