Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/4837
Title: | Characterization of 111In3+ complexes of DTPA amide derivatives: biodistribution and clearance studied by gamma imaging | Authors: | Prata, M. I. M. Santos, A. C. Bligh, S. W. A. Chowdhury, A. H. M. S. Geraldes, C. F. G. C. Lima, J. J. P. de |
Keywords: | Albumin; Gamma imaging; 111In3+ complexes; DTPA derivatives | Issue Date: | 2000 | Citation: | Nuclear Medicine and Biology. 27:6 (2000) 605-610 | Abstract: | A large series of structurally related diethylenetriaminepentaacetic acid amide derivatives with different structures and lipophilic properties were synthesized and radiolabeled with 111In3+. Two of the more hydrophobic compounds studied ([111In]L9 and [111In]L10) showed high affinity for human serum albumin (HSA). The biodistribution and clearance properties shown by all complexes upon injection in Wistar rats were followed by gamma imaging. The blood retention time of the chelates correlates better with their binding to HSA than with their hydrophilic/lipophilic ratio. Hydrophilic and negatively charged complexes undergo renal retention, while the majority of the lipophilic complexes are retained in the blood for a longer period of time and are cleared through the liver. | URI: | https://hdl.handle.net/10316/4837 | DOI: | 10.1016/S0969-8051(00)00127-X | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
file5dd665cf654a4dd1a605817dc1fd04dc.pdf | 344.59 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
10
checked on Sep 23, 2024
WEB OF SCIENCETM
Citations
9
checked on Sep 2, 2024
Page view(s) 20
729
checked on Sep 24, 2024
Download(s)
389
checked on Sep 24, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.