Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/5771
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Silva, M. Manuel Cruz | - |
dc.contributor.author | Melo, M. Luísa Sá e | - |
dc.contributor.author | Parolin, Marco | - |
dc.contributor.author | Tessaro, Davide | - |
dc.contributor.author | Riva, Sergio | - |
dc.contributor.author | Danieli, Bruno | - |
dc.date.accessioned | 2008-09-26T17:41:28Z | - |
dc.date.available | 2008-09-26T17:41:28Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Tetrahedron: Asymmetry. 15:1 (2004) 21-27 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/5771 | - |
dc.description.abstract | The enzyme-mediated preparation of enantiomerically or diastereomerically enriched polycyclic cyanohydrins has been investigated. Oxynitrilase-catalyzed cyanurations gave excellent results with the bicyclic aldehydes tested. On the other hand, enantio- or diastereoselective acylation, catalyzed by lipase PS or subtilisin, proved to be a more versatile methodology, giving good results even with sterically hindered polycyclic cyanohydrins. Specifically, the steroidal cyanohydrin derivative 4b was isolated with a 89% de. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6THT-4B53Y32-2/1/840d22acaac2079965efb41cc790103e | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.title | The biocatalyzed stereoselective preparation of polycyclic cyanohydrins | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/j.tetasy.2003.11.003 | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-1938-4150 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
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file42ab76357605461bad2204cc7e2f9431.pdf | 299.85 kB | Adobe PDF | View/Open |
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