Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/93152
DC Field | Value | Language |
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dc.contributor.author | Ribeiro, Luís F. | - |
dc.contributor.author | Catarino, Tatiana | - |
dc.contributor.author | Carvalho, Mário | - |
dc.contributor.author | Cortes, Luísa | - |
dc.contributor.author | Santos, Sandra D. | - |
dc.contributor.author | Opazo, Patricio O. | - |
dc.contributor.author | Ribeiro, Lyn Rosenbrier | - |
dc.contributor.author | Oliveiros, Bárbara | - |
dc.contributor.author | Choquet, Daniel | - |
dc.contributor.author | Esteban, José A. | - |
dc.contributor.author | Peça, João | - |
dc.contributor.author | Carvalho, Ana Luísa | - |
dc.date.accessioned | 2021-02-17T14:34:18Z | - |
dc.date.available | 2021-02-17T14:34:18Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1945-0877 | pt |
dc.identifier.issn | 1937-9145 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/93152 | - |
dc.description.abstract | The biological signals of hunger, satiety, and memory are interconnected. The role of the hormone ghrelin in regulating feeding and memory makes ghrelin receptors attractive targets for associated disorders. We investigated the effects of the high ligand-independent activity of the ghrelin receptor GHS-R1a on the physiology of excitatory synapses in the hippocampus. Blocking this activity produced a decrease in the synaptic content of AMPA receptors in hippocampal neurons and a reduction in GluA1 phosphorylation at Ser845. Reducing the ligand-independent activity of GHS-R1a increased the surface diffusion of AMPA receptors and impaired AMPA receptor–dependent synaptic delivery induced by chemical long-term potentiation. Accordingly, we found that blocking this GHS-R1a activity impaired spatial and recognition memory in mice. These observations support a role for the ligand-independent activity of GHS-R1a in regulating AMPA receptor trafficking under basal conditions and in the context of synaptic plasticity that underlies learning. | pt |
dc.language.iso | eng | pt |
dc.publisher | American Association for the Advancement of Science | pt |
dc.relation | IF/00812/2012 | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.title | Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation | pt |
dc.type | article | - |
degois.publication.firstPage | eabb1953 | pt |
degois.publication.issue | 670 | pt |
degois.publication.title | Science Signaling | pt |
dc.relation.publisherversion | https://stke.sciencemag.org/content/14/670/eabb1953/tab-pdf | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1126/scisignal.abb1953 | pt |
degois.publication.volume | 14 | pt |
dc.date.embargo | 2021-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.project.grantno | CENTRO-01-0145-FEDER-000008 | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-7836-8161 | - |
crisitem.author.orcid | 0000-0003-4989-2129 | - |
crisitem.author.orcid | 0000-0001-8368-6666 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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BrainHealth 2020-video.mp4 | 126.18 MB | Unknown | View/Open | |
Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation_accepted version.pdf | 2.7 MB | Adobe PDF | View/Open |
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