Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/95080
DC Field | Value | Language |
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dc.contributor.author | Simoes, Ines C M | - |
dc.contributor.author | Morciano, Giampaolo | - |
dc.contributor.author | Lebiedzinska-Arciszewska, Magdalena | - |
dc.contributor.author | Aguiari, Gianluca | - |
dc.contributor.author | Pinton, Paolo | - |
dc.contributor.author | Potes, Yaiza | - |
dc.contributor.author | Wieckowski, Mariusz R. | - |
dc.date.accessioned | 2021-06-21T11:52:05Z | - |
dc.date.available | 2021-06-21T11:52:05Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 09254439 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/95080 | - |
dc.description.abstract | Mitochondria-associated membranes (MAM), physical platforms that enable communication between mitochondria and the endoplasmic reticulum (ER), are enriched with many proteins and enzymes involved in several crucial cellular processes, such as calcium (Ca2+) homeostasis, lipid synthesis and trafficking, autophagy and reactive oxygen species (ROS) production. Accumulating studies indicate that tumor suppressors and oncogenes are present at these intimate contacts between mitochondria and the ER, where they influence Ca2+ flux between mitochondria and the ER or affect lipid homeostasis at MAM, consequently impacting cell metabolism and cell fate. Understanding these fundamental roles of mitochondria-ER contact sites as important domains for tumor suppressors and oncogenes can support the search for new and more precise anticancer therapies. In the present review, we summarize the current understanding of basic MAM biology, composition and function and discuss the possible role of MAM-resident oncogenes and tumor suppressors. | pt |
dc.language.iso | eng | pt |
dc.relation | Polish National Science Centre grant UMO- 2018/29/B/NZ1/00589 | pt |
dc.relation | Marie Skłodowska-Curie Grant Agreement No. 722619 (FOIE GRAS) | pt |
dc.relation | Marie Skłodowska-Curie Grant Agreement No. 734719 (mtFOIE GRAS) | pt |
dc.relation | Polish National Science Centre grant (UMO-2015/17/D/NZ1/00030) | pt |
dc.relation | Italian Association for Cancer Research (AIRC, IG-23670), | pt |
dc.relation | Telethon (GGP11139B) | pt |
dc.relation | Progetti di Rilevante Interesse Nazionale (PRIN, 2017 E5L5P3) | pt |
dc.rights | embargoedAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.subject | Cancer; Endoplasmic reticulum; Mitochondria; Mitochondria-associated membranes (MAM); Oncogenes; Oncosuppressors | pt |
dc.subject.mesh | Autophagy | pt |
dc.subject.mesh | Calcium Signaling | pt |
dc.subject.mesh | Endoplasmic Reticulum | pt |
dc.subject.mesh | Homeostasis | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Lipid Metabolism | pt |
dc.subject.mesh | Mitochondria | pt |
dc.subject.mesh | Mitochondrial Membranes | pt |
dc.subject.mesh | Neoplasms | pt |
dc.subject.mesh | Protein Transport | pt |
dc.subject.mesh | Reactive Oxygen Species | pt |
dc.title | The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective | pt |
dc.type | article | - |
degois.publication.firstPage | 165834 | pt |
degois.publication.issue | 10 | pt |
degois.publication.title | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | pt |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/abs/pii/S0925443920301794 | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.bbadis.2020.165834 | pt |
degois.publication.volume | 1866 | pt |
dc.date.embargo | 2021-10-01 | * |
uc.date.periodoEmbargo | 365 | pt |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | info:eu-repo/grantAgreement/EC/H2020/722619/EU/Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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IS_Accepted-1-41.pdf | 508.78 kB | Adobe PDF | View/Open |
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