Abrunhosa, Antero

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Credit Name
Abrunhosa, Antero
 
Name
Abrunhosa, Antero
 
Variants
Abrunhosa, Antero J.
 
Unidade de I&D
 
ORCID
 
Ciência ID
 
Scopus Author ID
 
Status
UC Researcher
Biography
First degree in Biochemistry (1992) and MSc in Biomedical Engineering (1996) from the University of Coimbra, Portugal. PhD work under Prof. Terry Jones’ supervision at the MRC - Cyclotron Unit, Hammersmith Hospital in London, UK (2002). From 2000 to 2009, helped to design and supervised the construction of the Institute for Nuclear Sciences Applied to Health (ICNAS) a leading facility in Portugal for Nuclear Imaging based at the University of Coimbra. He is the current Director of the Institute and the head of the Radiochemistry Laboratory (RCL). ICNAS has extensive expertise in the development of radiopharmaceuticals for Oncology, Cardiology and Neuroscience and is fully equipped for clinical imaging (2 PET/CT and a 3T MR) as well as pre-clinical studies (including an in-house developed world leading high-resolution small animal PET with 0.3 mm resolution, a 9.4T micro-MRI, an optical imaging system and a photoacoustic tomography device). The RCL hosts 2 cyclotrons (IBA cyclone 18/9 and the first IBA Kiube variable energy, installed in 2019) and is fully licensed as a GMP manufacturing site, currently producing more than 20 different tracers based on 11C, 13N, 18F, 68Ga, 61Cu and 64Cu. The facility is the main supplier of PET radiopharmaceuticals for Portugal, through its subsidiary (ICNAS-P, a company fully owned by the University) that currently has 6 radiopharmaceuticals in the market (FDG, FCH, NaF, 68Ga-DOTANOC, 68Ga-PSMA-11 and F-DOPA). Antero is manager and Head of Production for ICNAS-P from the start. Antero’s research interests include development of targeted probes for molecular imaging, PET, SPECT, radiopharmaceutical development, PET Radiopharmacy and Quality Control, pre-clinical imaging and clinical trials. The Institute is currently participating in more than 30 clinical trials and has recently received approval, by the authorities, of its first investigator driven clinical trial. Regarding technology transfer, Antero promoted the start of 3 spin-off companies from the University of Coimbra, one of them (Fluidomica, Lda) specializes in supplying target solutions for radiometal production. He is a member of the European Pharmacopoeia Group 14 and an Expert in several Technical Committees and Field Missions for IAEA (International Atomic Energy Agency). He currently holds patents in Europe, US and Japan regarding the production of gallium-68 using liquid targets.
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Publications
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Results 1-35 of 35 (Search time: 0.55 seconds).

Issue DateTitleAuthor(s)TypeAccess
120-May-2022Advanced Microwave Technology in Radiopharmaceutical SynthesisNeves, Ângela Cristina BarrôcodoctoralThesisembargoedAccess
210-Mar-2021Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPANeves, Ângela C. B. ; Hrynchak, Ivanna ; Fonseca, Inês ; Alves, Vítor H. P. ; Pereira, Mariette M. ; Falcão, Amílcar ; Abrunhosa, Antero J. articleopenAccess
310-Nov-2022An RPC-PET brain scanner demonstrator: first resultsFonte, Paulo ; Lopes, Luís ; Alves, Rui ; Carolino, Nuno ; Crespo, Paulo ; Couceiro, Miguel ; Cunha, Orlando ; Dias, Nuno ; Ferreira, Nuno C. ; Fetal, Susete ; Lopes, Ana L. ; Michel, Jan; Moreira, Jorge ; Pereira, Américo ; Saraiva, João ; Silva, Carlos ; Silva, Magda ; Traxler, Michael; Abrunhosa, Antero ; Blanco, Alberto ; Castelo-Branco, Miguel ; Pimenta, MárioarticleopenAccess
49-Jun-2023Antibody and Nanobody Radiolabeling with Copper-64: Solid vs. Liquid Target ApproachHrynchak, Ivanna ; Cocioabă, Diana; Fonseca, Alexandra I. ; Leonte, Radu; Carmo, Sérgio do ; Cornoiu, Roxana; Falcão, Amílcar ; Niculae, Dana; Abrunhosa, Antero articleopenAccess
52010Aspectos do controlo da qualidade da fluodesoxiglucose num laboratório de produçãoRodrigues, M. C. ; Clemente, G. ; Oterelo, J. P. ; Abrunhosa, A. ; Rodrigues, A. conferenceObjectopenAccess
62018Automated Purification of Radiometals Produced by Liquid TargetsAlves, Vítor H. P. ; Carmo, Sérgio do ; Alves, Francisco ; Abrunhosa, Antero articleopenAccess
713-Apr-2021Automatic classification of idiopathic Parkinson's disease and atypical parkinsonian syndromes combining [11C]raclopride PET uptake and MRI grey matter morphometryMartins, Ricardo Filipe Alves ; Oliveira, Francisco Paulo Marques de ; Moreira, Fradique Vieira de Almeida ; Moreira, Ana Paula ; Abrunhosa, Antero José Pena Afonso de ; Santos, Maria Cristina Januário ; Castelo-Branco, Miguel articleopenAccess
82021Combined Structural MR and Diffusion Tensor Imaging Classify the Presence of Alzheimer's Disease With the Same Performance as MR Combined With Amyloid Positron Emission Tomography: A Data Integration ApproachAgostinho, Daniel ; Caramelo, Francisco ; Moreira, Ana Paula ; Santana, Isabel ; Abrunhosa, Antero ; Castelo Branco, Miguel articleopenAccess
92020Copper-64 Chloride Exhibits Therapeutic Potential in Three-Dimensional Cellular Models of Prostate CancerPinto, Catarina I. G.; Bucar, Sara; Alves, Vítor H. P. ; Fonseca, Alexandra ; Abrunhosa, Antero J. ; da Silva, Cláudia L.; Guerreiro, Joana F.; Mendes, FilipaarticleopenAccess
1020-May-2021Correction to: Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPANeves, Ângela C. B. ; Hrynchak, Ivanna ; Fonseca, Inês ; Alves, Vítor H. P. ; Pereira, Mariette M. ; Falcão, Amílcar ; Abrunhosa, Antero J. articleopenAccess
112018Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aβ speciesOliveira, Francisco ; Leuzy, Antoine; Castelhano, J. ; Chiotis, Konstantinos; Hasselbalch, Steen Gregers; Rinne, Juha; Mendonça, Alexandre de ; Otto, Markus; Lleó, Alberto ; Santana, Isabel ; Johansson, Jarkko; Anderl-Straub, Sarah; Arnim, Christine; Beer, Ambros; Blesa, Rafael ; Fortea, Juan; Sanna-Kaisa, Herukka; Portelius, Erik; Pannee, Josef; Zetterberg, Henrik; Blennow, Kaj; Moreira, Ana P. ; Abrunhosa, Antero ; Nordberg, Agneta; Castelo-Branco, Miguel articleopenAccess
1226-Apr-2022Improved Characteristics of RANKL Immuno-PET Imaging Using Radiolabeled Antibody Fab FragmentsDewulf, Jonatan; Hrynchak, Ivanna ; Geudens, Sarah; Pintelon, Isabel; Vangestel, Christel; Sereno, José ; van Dam, Peter A; Abrunhosa, Antero ; Elvas, Filipe ; Van den Wyngaert, TimarticleopenAccess
1311-Dec-2020In Vivo Tracking of Extracellular Vesicles by Nuclear Imaging: Advances in Radiolabeling StrategiesAlmeida, Sara ; Santos, Liliana ; Falcão, Amílcar ; Gomes, Célia M. ; Abrunhosa, Antero J. articleopenAccess
1423-Jan-2021Investigating the Spatial Associations Between Amyloid-β Deposition, Grey Matter Volume, and Neuroinflammation in Alzheimer's DiseaseJorge, Lília ; Martins, Ricardo Filipe Alves ; Canário, Nádia ; Xavier, Carolina; Abrunhosa, Antero José Pena Afonso de ; Santana, Isabel ; Castelo-Branco, Miguel articleopenAccess
1510-Sep-2019Labelling and validation of [61Cu]DOTA-NOC for somatostatin receptors imagingFonseca, Alexandra Isabel SimõesmasterThesisembargoedAccess
1619-Jan-2021A link between synaptic plasticity and reorganization of brain activity in Parkinson's diseaseRebelo, Diliana ; Oliveira, Francisco ; Abrunhosa, Antero ; Januário, Cristina ; Lemos, João ; Castelo-Branco, Miguel articleopenAccess
172002Métodos computacionais no desenvolvimento de radiofármacos para a tomografia por emissão de positrões.Abrunhosa, Antero José Pena Afonso de doctoralThesisembargoedAccess
184-Oct-2021Nanobody-Based Theranostic Agents for HER2-Positive Breast Cancer: Radiolabeling StrategiesHrynchak, Ivanna ; Santos, Liliana ; Falcão, Amílcar ; Gomes, Célia M. ; Abrunhosa, Antero J. articleopenAccess
192009Nanorradiolipossomas modulados molecularmente para estudar a drenagem linfática pulmonar profundaBotelho, Maria Filomena ; Marques, Maria Alcide Tavares ; Gomes, Célia Maria Freitas ; Silva, Augusto Marques Ferreira da; Bairos, Vasco António Andrade Figueiredo de ; Rosa, Manuel Amaro dos Santos ; Abrunhosa, Antero Pena ; Lima, João José Pedroso de articleopenAccess
2018-Jun-2020Novos biomarcadores morfométricos do cerebelo por ressonância magnética: validação na doença de Machado-JosephFaustino, Ricardo Jorge FerreiradoctoralThesisopenAccess
2129-Apr-2022Nucleolin Overexpression Predicts Patient Prognosis While Providing a Framework for Targeted Therapeutic Intervention in Lung CancerFernandes, Ângela Valério ; Fonseca, Nuno A. ; Gonçalves, Nélio ; Cruz, Ana F. ; Pereira, Marta I. ; Gregório, Ana C. ; Moura, Vera ; Ladeirinha, Ana F. ; Alarcão, Ana ; Gonçalves, Joana ; Abrunhosa, Antero ; Melo, Joana B. ; Carvalho, Lina ; Simões, Sérgio ; Moreira, João N. articleopenAccess
222012Optimisation of synthesis, purification and reformulation of (R)-[N-methyl-¹¹C] PK11195 for in vivo PET imaging studiesAlves, Vítor Hugo Pereira masterThesisopenAccess
2319-Jun-2019A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesiclesBanerjee, Arnab; Alves, Vitor; Rondão, Tiago; Sereno, José; Neves, Ângela; Lino, Miguel ; Ribeiro, Andreia; Abrunhosa, Antero ; Ferreira, Lino articleembargoedAccess
246-Dec-2019Production and purification of radiometals for theranostics via liquid target in a medical cyclotronAlves, Vítor Hugo PereiradoctoralThesisembargoedAccess
2511-Nov-2018Radiobiological Characterization of 64CuCl₂ as a Simple Tool for Prostate Cancer TheranosticsGuerreiro, Joana Fernandes; Alves, Vítor ; Abrunhosa, Antero José ; Paulo, António; Gil, Octávia Monteiro; Mendes, FilipaarticleopenAccess
26Dec-2013Radiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzoxazole derivative for β-amyloid targetingMorais, G. Ribeiro ; Gano, L. ; Kniess, T. ; Bergmann, R. ; Abrunhosa, A. ; Santos, I. ; Paulo, A. articleopenAccess
272010Síntese de [18F]-FDG no módulo syntheraFernandes, E. ; Vitório, R. ; Oterelo, J. P. ; Clemente, G. ; Rodrigues, M. C. ; Guerreiro, C. ; Abrunhosa, A. ; Rodrigues, A. conferenceObjectopenAccess
2811-Jul-2014Síntese de macrociclos tetrapirrólicos fluorados. Desenvolvimento de potenciais marcadores para tomografia por emissão de positrõesSimões, Ana Vanessa Cordeiro doctoralThesisopenAccess
292010Síntese e purificação de [11C]-racloprideClemente, G. ; Oterelo, J. P. ; Rodrigues, M. C. ; Abrunhosa, A. ; Rodrigues, A. conferenceObjectopenAccess
301-Aug-2018Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cellsRodrigues, Carlos F. D. ; Serrano, Eurico ; Patrício, Maria I.; Val, Mariana; Albuquerque, Patrícia; Fonseca, João ; Gomes, Célia M. F. ; Abrunhosa, Antero ; Paiva, Artur ; Carvalho, Lina ; Botelho, Maria F. ; Almeida, Luís ; Carreira, Isabel M. ; Alpoim, Maria Carmen articleopenAccess
3127-Feb-2020Synthesis Optimisation of High Specific Activity Carbon-11 Radiopharmaceuticals for Brain PET StudiesRodrigues, Iolanda Beatriz AlbuquerquemasterThesisopenAccess
322017Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypesGonçalves, Joana ; Violante, Inês R. ; Sereno, José ; Leitão, Ricardo A. ; Cai, Ying; Abrunhosa, Antero ; Silva, Ana Paula ; Silva, Alcino J.; Castelo-Branco, Miguel articleopenAccess
336-May-2023Textural properties of microglial activation in Alzheimer's disease as measured by (R)-[11C]PK11195 PETLapo Pais, Marta; Jorge, Lília ; Martins, Ricardo ; Canário, Nádia ; Xavier, Ana Carolina; Bernardes, Rui ; Abrunhosa, Antero ; Santana, Isabel; Castelo-Branco, Miguel articleopenAccess
34Apr-2023The association of collaterals with myocardial ischemia and viability in chronic total occlusionsLeite, Luís ; Campos, Gustavo; Silva, Rodolfo; Jorge, Elisabete ; Oliveira-Santos, Manuel ; Gomes, Andreia ; Gonçalves, Lino ; Castelo-Branco, Miguel ; Abrunhosa, Antero ; Ferreira, Maria João articleopenAccess
354-Apr-2012Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell lineMartins-Neves, Sara R. ; Lopes, Áurio ; Carmo, Anália do ; Paiva, Artur A. ; Simões, Paulo C.; Abrunhosa, Antero ; Gomes, Célia M. F. articleopenAccess