Ferreiro, Elisabete

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Credit Name
Ferreiro, Elisabete
 
Name
Ferreiro, Elisabete
 
Personal Site
http://www.cnbc.pt/research/department_group_show.asp?iddep=1138&idgrp=1141
 
ORCID
 
Ciência ID
 
Status
UC Researcher
Biography
Elisabete Ferreiro is currently an assistant researcher at the Center for Neuroscience and Cell Biology, University of Coimbra, integrated in the group MitoXT - Mitochondrial Toxicology and Experimental Therapeutics, headed by Dr.Paulo Oliveira. She graduated in Biology from the University of Coimbra (UC), in 2002, and completed her PhD degree in Biology, also from UC, in 2008. Her main expertise area is in neuroscience and cell biology. Her research in the past years has been focused on identifying mechanisms involved in Alzheimer's disease (AD) and potential therapeutic targets for the treatment of this neurodegenerative disease. She was also interested in exploring hippocampal adult neurogenesis along with signalling pathways with potential to improve upon it. Her PhD works, supervised by Prof. Claudia Fragão Pereira (Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra) led to the thesis 'Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by amyloid-beta and prion peptides. Implications for the etiopathogenesis of Alzheimer’s disease and Prion disorders'. During her PhD works, E. Ferreiro demonstrated the existence of endoplasmic reticulum (ER) stress as a major contribution for cell death induced by the amyloid beta (Abeta) peptide and PrP106–126, in both Alzheimer’s disease and Prion disorders. Besides, she further showed the relevance of the communication between the ER and the mitochondria for apopotic pathway. In 2008, E. Ferreiro started her post-doc research program in order to characterize the stem and progenitor properties that contribute for decreased neurogenesis in the triple transgenic mouse model of AD. In 2013, initiated a second postdoctoral program in the group of Dr Ana Cristina Rego (Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra). During this period Elisabete Ferreiro studied the mitochondrial control of NMDA receptor-dependent calcium rise evoked by amyloid-ß 1-42 oligomers in rat cortical neurons and also evaluated whether hyperglycemia enhances AD pathology by modifying NMDARs signaling and function, and consequently affecting neurogenesis. In 2015, E Ferreiro joined the COST action BM1402, and was an active member and establishing several collaborations and short-term exchanges. In 2017 she spent 6 months at the Achucarro Basque Center (Spain), where she extended her knowledge on hippocampal neurogenesis, and consolidate her ollaborations with experts in the field. Currently, she is currently interested in developing new therapeutic strategies, for other Neurodegenerative diseases, such as Amyotrophic lateral sclerosis. As a result of her research activity, she has published 32 scientific papers in international peer reviewed journals, with over 2122 citations and a h index of 21.
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Publications
(Todas)

Resultados 1-19 de 19.

Data de publicaçãoTítuloAutor(es)TipoAcesso
1Dez-2013Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–40 peptide in brain endothelial cellsFonseca, Ana Catarina R. G. ; Ferreiro, Elisabete ; Oliveira, Catarina R. ; Cardoso, Sandra M. ; Pereira, Cláudia F. articleopenAccess
2Fev-2015Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium releaseFerreira, Ildete Luísa ; Ferreiro, Elisabete ; Schmidt, Jeannette ; Cardoso, João M. ; Pereira, Cláudia M. F. ; Carvalho, Ana Luísa ; Oliveira, Catarina R. ; Rego, A. Cristina articleopenAccess
32004Cell degeneration induced by amyloid-ß peptidesPereira, Cláudia ; Ferreiro, Elisabete ; Cardoso, Sandra ; Oliveira, Catarina de articleopenAccess
4Ago-2020Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer's disease mouse modelFerreiro, Elisabete articleopenAccess
526-Abr-2019Chronic stress triggers divergent dendritic alterations in immature neurons of the adult hippocampus, depending on their ultimate terminal fieldsDioli, Chrysoula; Patrício, Patrícia; Sousa, Nuno; Kokras, Nikolaos; Dalla, Christina; Guerreiro, Sara ; Santos-Silva, Miguel A.; Rego, Ana Cristina ; Pinto, Luísa ; Ferreiro, Elisabete ; Sotiropoulos, IoannisarticleopenAccess
631-Ago-2018Coriolus versicolor biomass increases dendritic arborization of newly-generated neurons in mouse hippocampal dentate gyrusFerreiro, Elisabete ; Pita, Inês R. ; Mota, Sandra ; Valero, Jorge ; Ferreira, Nuno R. ; Fernandes, Tito; Calabrese, Vittorio; Fontes-Ribeiro, Carlos A. ; Pereira, Frederico C. ; Rego, Ana Cristina articleopenAccess
73-Jul-2008Cross-talk between endoplasmic reticulum and mitochondria in th neurotoxicity induced by amyloid-beta and prion peptides : implications for the etiopathogenesis of Alzheimer's disease and prion disordersFerreiro, Elisabete Baptista doctoralThesisembargoedAccess
82022Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD MiceFernandes, Adelaide; Caldeira, Cláudia; Cunha, Carolina; Ferreiro, Elisabete ; Vaz, Ana Rita; Brites, Dora articleopenAccess
92006An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicityFerreiro, Elisabete ; Resende, Rosa ; Costa, Rui ; Oliveira, Catarina R. ; Pereira, Cláudia M. F. articleopenAccess
102008ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylationResende, Rosa ; Ferreiro, Elisabete ; Pereira, Cláudia ; Oliveira, Catarina Resende articleopenAccess
112004Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-beta peptideFerreiro, Elisabete ; Oliveira, Catarina R. ; Pereira, Cláudia articleopenAccess
122014Involvement of vascular dysfunction in the neurogenesis impairment that occurs in Alzheimer’s diseaseFontes, Ana Raquel masterThesisopenAccess
136-Mar-2020miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer's DiseaseBarros-Viegas, Ana Teresa ; Carmona, Vitor ; Ferreiro, Elisabete ; Guedes, Joana ; Cardoso, Ana Maria S. ; Cunha, Pedro ; Almeida, Luís Pereira de ; Oliveira, Catarina Resende de ; Magalhães, João Pedro de ; Peça, João ; Cardoso, Ana Luísa articleopenAccess
142012Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkersFerreiro, E. ; Baldeiras, I. ; Ferreira, I. L. ; Costa, R. O. ; Rego, A. C. ; Pereira, C. F. ; Oliveira, C. R. articleopenAccess
151-Set-2008Neurotoxic effect of oligomeric and fibrillar species of A<beta>1-42 peptide. Involvement of ER calcium release in oligomers-induced cell death.Resende, Rosa ; Ferreiro, Elisabete ; Pereira, Cláudia ; Oliveira, Catarina Resende de articleopenAccess
161-Jul-2023Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent PerspectivesAfonso, Gonçalo; Cavaleiro, Carla ; Valero, Jorge ; Mota, Sandra ; Ferreiro, E. articleopenAccess
172008The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathwayFerreiro, Elisabete ; Oliveira, Catarina R. ; Pereira, Cláudia M. F. articleopenAccess
18Out-2017Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampusRobledinos-Antón, Natalia; Rojo, Ana I; Ferreiro, Elisabete ; Núñez, Ángel; Krause, Karl-Heinz; Jaquet, Vincent; Cuadrado, AntonioarticleopenAccess
192020Unraveling the Nanoscopic Organization and Function of Central Mammalian Presynapses With Super-Resolution MicroscopyCarvalhais, Lia G. ; Martinho, Vera C. ; Ferreiro, Elisabete ; Pinheiro, Paulo S. articleopenAccess