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https://hdl.handle.net/10316/101134
Título: | Antioxidant, Anti-Inflammatory, and Analgesic Activities of Agrimonia eupatoria L. Infusion | Autor: | Santos, Telmo N. Costa, Gustavo Ferreira, J. Pinto Liberal, Joana Francisco, Vera Paranhos, António Cruz, Maria T. Castelo-Branco, M. Figueiredo, I. Vitória Batista, M. Teresa |
Data: | 2017 | Editora: | Hindawi | Projeto: | PTDC/SAU-FCF/105429/2008 FCOMP-01-0124-FEDER-011096 PEst-OE/SAU/UI0177/2011 |
Título da revista, periódico, livro ou evento: | Evidence-Based Complementary and Alternative Medicine | Volume: | 2017 | Número: | 8309894 | Resumo: | Agrimony (Agrimonia eupatoria L.) (Ae) is used in traditional medicine to treat inflammatory and oxidative related diseases. T herefore, this study focuses on the anti-inflammatory and analgesic potential of Ae infusion (AeI). Phenolic compounds characterization was achieved by HPLC-PDA-ESI/MSn. To evaluate antioxidant potential, 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radical, and SNAP assays were used. In vitro anti-inflammatory activity of AeI was investigated in LPS-stimulated macrophages by measuring the NO production. In vivo anti-inflammatory activity was validated using the mouse carrageenan-induced paw edema model. Peripheral and central analgesic potential was evaluated using the acetic acid-induced writhing and hot-plate tests, respectively, as well as the formalin assay to assess both activities. The safety profile was disclosed in vitro andinvivo, usingMTTandhematoxylinassays,respectively.Vitexin,quercetin O-galloyl-hexoside, andkaempferol O-acetylhexosyl-rhamnoside were referred to in this species for the first time. AeI and mainly AePF (Ae polyphenolic fraction) showed a significant antiradical activity against all tested radicals. Both AeI and AePF decreased NO levels in vitro, AePF being more active than AeI. In vivo anti-inflammatory and analgesic activities were verified for both samples at concentrations devoid of toxicity. Agrimony infusion and, mainly, AePF are potential sources of antiradical and anti-inflammatory polyphenols. | URI: | https://hdl.handle.net/10316/101134 | DOI: | 10.1155/2017/8309894 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais I&D CIBIT - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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RIt-24_Antioxidant__Anti-Inflammatory__and_Analgesic_Activities_of_Agrimonia_eupatoria_L._Infusion_2017.pdf | 2.71 MB | Adobe PDF | Ver/Abrir |
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