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Title: | Evaluation of Anti-inflammatory and Analgesic Activities of Cymbopogon citratus In vivo-Polyphenols Contribution | Authors: | Garcia, Rita Ferreira, Joao Pinto Costa, Gustavo Santos, Telmo Branco, Fábio Caramona, Margarida Carvalho, Rui de Dinis, Augusto Manuel Batista, Maria Teresa Castel-Branco, Margarida Figueiredo, Isabel V. |
Keywords: | Cymbopogon citratus; lemongrass; in vivo; inflammation; pain; phenolic compounds | Issue Date: | 1-Jan-2015 | Publisher: | Academic Journals Inc. | Project: | FCOMP-01-0124-FEDER-011096 info:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC/SAU-FCF/105429/2008/PT/Anti-inflammatory mechanism and properties of medicinal plants: a multidisciplinary research for their validation and utilization as a source of phytopharmaceuticals info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE/SAU/UI0177/2011/PT/Strategic Project - UI 177 - 2011-2012 |
Serial title, monograph or event: | Research Journal of Medicinal Plant | Volume: | 9 | Issue: | 1 | Abstract: | Cymbopogon citratus is one of the most common herbs used in folk medicine due to its anti-inflammatory and antioxidant properties. Taking into account these properties showed on in vitro assays, the aim of this study was to evaluate the anti-inflammatory and analgesic activities of C. citratus leaves infusion (CcE) and its flavonoid-rich (CcF) and tannin-rich (CcT) fractions. The evaluation of the anti-inflammatory activity was performed in the carrageenan-induced rat paw oedema model. Both central and peripheral analgesic activities were evaluated in mice through the hot plate test and the acetic acid-induced writhing test, respectively. In the acute inflammation model, the statistically significant results obtained in percentage of oedema inhibition were 70.80 and 82.30% for CcE (34.12 and 68.24 mg kg , respectively), 59.00% for CcF 1 1 1 1 (7.42 mg kg ), 61.00% for CcT (5.96 mg kg ) and 84.00% for positive control group (10 mg kg ). For the peripheral pain evaluation, statistically significant results showed a pain 1 1 1 reduction of 57.00% for CcE (136.48 mg kg ), 54.60% for CcF (14.8 mg kg ), 52.20% for CcT (11.92 mg kg ) and 83.00% for positive control group. This study demonstrates that C. citratus infusion compounds are able to reduce inflammation and peripheral pain in vivo, with polyphenols showing a significant contribution for these activities. | URI: | https://hdl.handle.net/10316/101140 | ISSN: | 1819-3455 | DOI: | 10.3923/rjmp.2015.1.13 | Rights: | openAccess |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais I&D CEFarmacêuticos - Artigos em Revistas Internacionais I&D CFE - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais |
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