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https://hdl.handle.net/10316/101618
Título: | A mechanism for red coloration in vertebrates | Autor: | Toomey, Matthew B. Marques, Cristiana I. Araújo, Pedro M. Huang, Delai Zhong, Siqiong Liu, Yu Schreiner, Gretchen D. Myers, Connie A. Pereira, Paulo Afonso, Sandra Andrade, Pedro Gazda, Małgorzata A. Lopes, Ricardo J. Viegas, Ivan Koch, Rebecca E. Haynes, Maureen E. Smith, Dustin J. Ogawa, Yohey Murphy, Daniel Kopec, Rachel E. Parichy, David M. Carneiro, Miguel . Corbo, Joseph C. |
Data: | 25-Ago-2022 | Editora: | Elsevier; Cell Press | Projeto: | info:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST/00152/2018/PT info:eu-repo/grantAgreement/EC/H2020/101000504/EU/The Genetic, Cellular, and Photonic Mechanisms of Avian Structural Colouration 2020.01405.CEECIND/CP1601/CT0011 2020.01494.CEECIND PD/BD/ 114042/2015 PD/BD/28492/2017 info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH/BD/147030/2019/PT/The Colour of Cooperation: linking colour polymorphism to mutualistic behaviour in the Caribbean sharknose cleaning goby Elacatinus evelynae |
Título da revista, periódico, livro ou evento: | Current Biology | Resumo: | Red coloration is a salient feature of the natural world. Many vertebrates produce red color by converting dietary yellow carotenoids into red ketocarotenoids via an unknown mechanism. Here, we show that two enzymes, cytochrome P450 2J19 (CYP2J19) and 3-hydroxybutyrate dehydrogenase 1-like (BDH1L), are sufficient to catalyze this conversion. In birds, both enzymes are expressed at the sites of ketocarotenoid biosynthesis (feather follicles and red cone photoreceptors), and genetic evidence implicates these enzymes in yellow/red color variation in feathers. In fish, the homologs of CYP2J19 and BDH1L are required for ketocarotenoid production, and we show that these enzymes are sufficient to produce ketocarotenoids in cell culture and when ectopically expressed in fish skin. Finally, we demonstrate that the red-cone-enriched tetratricopeptide repeat protein 39B (TTC39B) enhances ketocarotenoid production when co-expressed with CYP2J19 and BDH1L. The discovery of this mechanism of ketocarotenoid biosynthesis has major implications for understanding the evolution of color diversity in vertebrates. | URI: | https://hdl.handle.net/10316/101618 | ISSN: | 09609822 | DOI: | 10.1016/j.cub.2022.08.013 | Direitos: | embargoedAccess |
Aparece nas coleções: | I&D CFE - Artigos em Revistas Internacionais I&D MARE - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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1-s2.0-S0960982222012908-main.pdf | 6.21 MB | Adobe PDF | Ver/Abrir |
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