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Título: | Identification of Antibiotics in Surface-Groundwater. A Tool towards the Ecopharmacovigilance Approach: A Portuguese Case-Study | Autor: | Viana, Paula Meisel, Leonor Lopes, Ana de Jesus, Rosário Sarmento, Georgina Duarte, Sofia Sepodes, Bruno Fernandes, Ana Dos Santos, Margarida M. Correia Almeida, Anabela Oliveira, M. Conceição |
Palavras-chave: | antibiotics; surface- groundwater; POCIS; ecopharmacovigilance; cilastatin; tazobactam; abacavir | Data: | 21-Jul-2021 | Editora: | MDPI | Projeto: | RNEM (Portuguese Mass Spectrometry Network) funding from LISBOA-01-0145-FEDER-022125-IST Project POSEUR-03-2013-FC-000001, programme “Melhoria da avaliação do estado das massas de água”; (2) APA (Agência Portuguesa do Ambiente) funding from POSEUR-03-2013-FC-000001, programme “Melhoria da Avaliação do Estado das Massas de Água”—“Aplicação de métodos inovadores na avaliação de compostos emergentes em massas de água superficiais e subterrâneas” |
Título da revista, periódico, livro ou evento: | Antibiotics | Volume: | 10 | Número: | 8 | Resumo: | Environmental monitoring, particularly of water, is crucial to screen and preselect potential hazardous substances for policy guidance and risk minimisation strategies. In Portugal, extensive data are missing. This work aimed to perform a qualitative survey of antibiotics in surface- groundwater, reflecting demographic, spatial, consumption and drug profiles during an observational period of three years. A passive sampling technique (POCIS) and high-resolution chromatographic system were used to monitor and analyse the antibiotics. The most frequently detected antibiotics were enrofloxacin/ciprofloxacin and tetracycline in surface-groundwater, while clarithromycin/erythromycin and sulfamethoxazole were identified only in surface water. The detection of enzyme inhibitors (e.g., tazobactam/cilastatin) used exclusively in hospitals and abacavir, a specific human medicine was also noteworthy. North (Guimarães, Santo Tirso and Porto) and South (Faro, Olhão and Portimão) Portugal were the regions with the most significant frequency of substances in surface water. The relatively higher detection downstream of the effluent discharge points compared with a low detection upstream could be attributed to a low efficiency in urban wastewater treatment plants and an increased agricultural pressure. This screening approach is essential to identify substances in order to perform future quantitative risk assessment and establishing water quality standards. The greatest challenge of this survey data is to promote an ecopharmacovigilance framework, implement measures to avoid misuse/overuse of antibiotics and slow down emission and antibiotic resistance. | URI: | https://hdl.handle.net/10316/103678 | ISSN: | 2079-6382 | DOI: | 10.3390/antibiotics10080888 | Direitos: | openAccess |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais I&D CIBIT - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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antibiotics-10-00888.pdf | 2.15 MB | Adobe PDF | Ver/Abrir |
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