Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/10398
Título: | Effect of Headgroup on DNA−Cationic Surfactant Interactions | Autor: | Dasgupta, Antara Das, Prasanta Kumar Dias, Rita S. Miguel, Maria G. Lindman, Björn Jadhav, Vaibhav M. Gnanamani, Muthaiah Maiti, Souvik |
Data: | 26-Jul-2007 | Editora: | American Chemical Society | Citação: | The Journal of Physical Chemistry B. 111:29 (2007) 8502-8508 | Resumo: | The interaction behavior of DNA with different types of hydroxylated cationic surfactants has been studied. Attention was directed to how the introduction of hydroxyl substituents at the headgroup of the cationic surfactants affects the compaction of DNA. The DNA−cationic surfactant interaction was investigated at different charge ratios by several methods like UV melting, ethidium bromide exclusion, and gel electrophoresis. Studies show that there is a discrete transition in the DNA chain from extended coils (free chain) to a compact form and that this transition does not depend substantially on the architecture of the headgroup. However, the accessibility of DNA to ethidium bromide is preserved to a significantly larger extent for the more hydrophilic surfactants. This was discussed in terms of surfactant packing. Observations are interpreted to reflect that the surfactants with more substituents have a larger headgroup and therefore form smaller micellar aggregates; these higher curvature aggregates lead to a less efficient, “patch-like” coverage of DNA. The more hydrophilic surfactants also presented a significantly lower cytotoxicity, which is important for biotechnological applications. | URI: | https://hdl.handle.net/10316/10398 | ISSN: | 1520-6106 | DOI: | 10.1021/jp068571m | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Química - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Effect of Headgroup on DNA-Cationic Surfactant Interactions.pdf | 146.2 kB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
81
Visto em 30/set/2024
Citações WEB OF SCIENCETM
1
72
Visto em 2/set/2024
Visualizações de página
307
Visto em 24/set/2024
Downloads
425
Visto em 24/set/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.