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https://hdl.handle.net/10316/108282
Título: | Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation | Autor: | Boto, Carlos Quartin, Emanuel Cai, Yijun Martín-Lorenzo, Alberto Cenador, María Begoña García Pinto, Sandra Gupta, Rajeev Enver, Tariq Sánchez-García, Isidro Hong, Dengli Neves, Ricardo Pires das Ferreira, Lino |
Data: | 11-Mai-2017 | Editora: | Springer Nature | Projeto: | PTDC/CTM-NAN/120552/2010 SFRH/BD/62419/2009 SFRH/BD/90964/2012 POCI-01- 0145-FEDER-016390:CANCEL STEM info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/NEU/04539/2013/PT |
Título da revista, periódico, livro ou evento: | Nature Communications | Volume: | 8 | Número: | 1 | Resumo: | Leukaemia cells that are resistant to conventional therapies are thought to reside in protective niches. Here, we describe light-inducible polymeric retinoic acid (RA)-containing nanoparticles (NPs) with the capacity to accumulate in the cytoplasm of leukaemia cells for several days and release their RA payloads within a few minutes upon exposure to blue/UV light. Compared to NPs that are not activated by light exposure, these NPs more efficiently reduce the clonogenicity of bone marrow cancer cells from patients with acute myeloid leukaemia (AML) and induce the differentiation of RA-low sensitive leukaemia cells. Importantly, we show that leukaemia cells transfected with light-inducible NPs containing RA can engraft into bone marrow in vivo in the proximity of other leukaemic cells, differentiate upon exposure to blue light and release paracrine factors that modulate nearby cells. The NPs described here offer a promising strategy for controlling distant cell populations and remotely modulating leukaemic niches. | URI: | https://hdl.handle.net/10316/108282 | ISSN: | 2041-1723 | DOI: | 10.1038/ncomms15204 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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Prolonged-intracellular-accumulation-of-lightinducible-nanoparticles-in-leukemia-cells-allows-their-remote-activationNature-Communications.pdf | 1.61 MB | Adobe PDF | Ver/Abrir |
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