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Title: | Implication of low HDL-c levels in patients with average LDL-c levels: a focus on oxidized LDL, large HDL subpopulation, and adiponectin | Authors: | Mascarenhas-Melo, Filipa Sereno, José Teixeira-Lemos, Edite Marado, Daniela Palavra, Filipe Pinto, Rui Rocha-Pereira, Petronila Teixeira, Frederico Reis, Flávio |
Issue Date: | 2013 | Publisher: | Hindawi | Project: | SFRH/ BD/65483/2009 PEst-C/SAU/UI3282/2011 |
Serial title, monograph or event: | Mediators of Inflammation | Volume: | 2013 | Abstract: | To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and the other of low HDL-c levels. The following data was analyzed: BP, BMI, waist circumference and serum glucose Total-c, TGs, LDL-c, oxidized LDL, total HDL-c and subpopulations (small, intermediate, and large), paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF- α , adiponectin, VEGF, and iCAM1. In the control subgroup with low HDL-c levels, significantly higher values of BP and TGs and lower values of PON1 activity and adiponectin were found, versus control normal HDL-c subgroup. However, differences in patients' subgroups were clearly more pronounced. Indeed, low HDL-c subgroup presented increased HbA1c, TGs, non-HDL-c, Ox-LDL, hsCRP, VEGF, and small HDL-c and reduced adiponectin and large HDL. In addition, Ox-LDL, large-HDL-c, and adiponectin presented interesting correlations with classical and nonclassical markers, mainly in the normal HDL-c patients' subgroup. In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin. | URI: | https://hdl.handle.net/10316/109752 | ISSN: | 0962-9351 1466-1861 |
DOI: | 10.1155/2013/612038 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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Implication-of-low-HDLc-levels-in-patients-with-average-LDLc-levels-A-focus-on-oxidized-LDL-large-HDL-subpopulation-and-adiponectinMediators-of-Inflammation.pdf | 4.37 MB | Adobe PDF | View/Open |
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