Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/110036
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Brigas, Amadeu F | - |
dc.contributor.author | Rosa da Costa, Ana M | - |
dc.contributor.author | Serra, Arménio | - |
dc.contributor.author | Pires, Catarina | - |
dc.date.accessioned | 2023-11-14T09:42:31Z | - |
dc.date.available | 2023-11-14T09:42:31Z | - |
dc.date.issued | 2011-04 | - |
dc.identifier.issn | 0975-7406 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/110036 | - |
dc.description.abstract | A number of new porphyrin-based photosensitizers have been developed for Photodynamic Therapy (PDT) in recent years. Chlorins, which are a reduced form of porphyrins, show better potential of application since they have a stronger absorption band on the red region of the visible spectrum and, hence, a deeper penetration into tissues. We found that by using heterogeneous catalytic transfer reduction (CTR), meso-tetraphenylporphyrin (TPP) could be hydrogenated, although in modest yields, to meso-tetraphenylchlorin (TPC) in a single reaction step. Best reaction conditions were attained using formic acid or sodium phosphinate/water as hydrogen donors, tetrahydrofuran (THF) or toluene as solvent and 10% palladium on charcoal as catalyst. | pt |
dc.language.iso | eng | pt |
dc.publisher | Wolters Kluwer Health | pt |
dc.relation | FCT – Portugal through CIQA, Centre for Research in Chemistry of Algarve | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | pt |
dc.subject | Catalytic transfer reduction | pt |
dc.subject | hydrogenation | pt |
dc.subject | meso-tetraphenylchlorin | pt |
dc.subject | meso-tetraphenylporphyrin | pt |
dc.subject | photosensitizers | pt |
dc.title | Photosensitizers for photodynamic therapy: One-pot heterogeneous catalytic transfer reduction of porphyrins | pt |
dc.type | article | - |
degois.publication.firstPage | 294 | pt |
degois.publication.lastPage | 297 | pt |
degois.publication.issue | 2 | pt |
degois.publication.title | Journal of Pharmacy and Bioallied Sciences | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.4103/0975-7406.80770 | pt |
degois.publication.volume | 3 | pt |
dc.date.embargo | 2011-04-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CEMMPRE - Centre for Mechanical Engineering, Materials and Processes | - |
crisitem.author.orcid | 0000-0001-8664-2757 | - |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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photosensitizers_for_photodynamic_therapy__one_pot.18.pdf | 488.18 kB | Adobe PDF | View/Open |
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