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https://hdl.handle.net/10316/110036
Título: | Photosensitizers for photodynamic therapy: One-pot heterogeneous catalytic transfer reduction of porphyrins | Autor: | Brigas, Amadeu F Rosa da Costa, Ana M Serra, Arménio Pires, Catarina |
Palavras-chave: | Catalytic transfer reduction; hydrogenation; meso-tetraphenylchlorin; meso-tetraphenylporphyrin; photosensitizers | Data: | Abr-2011 | Editora: | Wolters Kluwer Health | Projeto: | FCT – Portugal through CIQA, Centre for Research in Chemistry of Algarve | Título da revista, periódico, livro ou evento: | Journal of Pharmacy and Bioallied Sciences | Volume: | 3 | Número: | 2 | Resumo: | A number of new porphyrin-based photosensitizers have been developed for Photodynamic Therapy (PDT) in recent years. Chlorins, which are a reduced form of porphyrins, show better potential of application since they have a stronger absorption band on the red region of the visible spectrum and, hence, a deeper penetration into tissues. We found that by using heterogeneous catalytic transfer reduction (CTR), meso-tetraphenylporphyrin (TPP) could be hydrogenated, although in modest yields, to meso-tetraphenylchlorin (TPC) in a single reaction step. Best reaction conditions were attained using formic acid or sodium phosphinate/water as hydrogen donors, tetrahydrofuran (THF) or toluene as solvent and 10% palladium on charcoal as catalyst. | URI: | https://hdl.handle.net/10316/110036 | ISSN: | 0975-7406 | DOI: | 10.4103/0975-7406.80770 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Química - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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photosensitizers_for_photodynamic_therapy__one_pot.18.pdf | 488.18 kB | Adobe PDF | Ver/Abrir |
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