Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/110976
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Prata, M. I. M. | - |
dc.contributor.author | Ribeiro, M. J. | - |
dc.contributor.author | Santos, A. C. | - |
dc.contributor.author | Peters, J. A. | - |
dc.contributor.author | Nepveu, F. | - |
dc.contributor.author | Geraldes, C. F. G. C. | - |
dc.contributor.author | Lima, J. J. P. de | - |
dc.date.accessioned | 2023-11-29T11:17:58Z | - |
dc.date.available | 2023-11-29T11:17:58Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0793-0291 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/110976 | - |
dc.description.abstract | Aiming at radiopharmaceutical application, (111)In(3+) complexes of the polyaminocarboxylates TTHA, TTHA-bis(butylamide) and TTHA-bis(glucamide) were investigated. The in vitro stability of (111)In(TTHA)(3-) and (111)In(TTHA-bis(butylamide)(-) was evaluated by measuring the exchange of (111)In(3+) from the complexes to transferrin and the results were compared with those for (111)In(DTPA)(2-). We also performed biodistribution studies of the three (111)In(3+) complexes by gamma-imaging in Wistar rats and by measuring the radioactivity in their organs. TTHA and its derivatives seem to have similar in vivo biodistribution with prevailing renal excretion. | pt |
dc.language.iso | eng | pt |
dc.publisher | Hindawi | pt |
dc.relation | FCT - Praxis XXI project 2/2.2/SAU/1194/95 | pt |
dc.relation | BIOMED II (MACE Project) | pt |
dc.relation | COST Chemistry D8 Program of the European Union | pt |
dc.relation | I’Association pour a Recherche contre le Cancer (ARC) | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.title | In Vitro and In Vivo Behaviour of In Complexes of TTHA, TTHA-Bis(Butylamide) and TTHA-Bis(Glucamide): Stability, Biodistribution and Excretion Studied by Gamma Imaging | pt |
dc.type | article | - |
degois.publication.firstPage | 259 | pt |
degois.publication.lastPage | 264 | pt |
degois.publication.issue | 5 | pt |
degois.publication.title | Metal-Based Drugs | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1155/MBD.1998.259 | pt |
degois.publication.volume | 5 | pt |
dc.date.embargo | 1998-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0003-2888-0073 | - |
crisitem.author.orcid | 0000-0002-0837-8329 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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