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https://hdl.handle.net/10316/110976
Título: | In Vitro and In Vivo Behaviour of In Complexes of TTHA, TTHA-Bis(Butylamide) and TTHA-Bis(Glucamide): Stability, Biodistribution and Excretion Studied by Gamma Imaging | Autor: | Prata, M. I. M. Ribeiro, M. J. Santos, A. C. Peters, J. A. Nepveu, F. Geraldes, C. F. G. C. Lima, J. J. P. de |
Data: | 1998 | Editora: | Hindawi | Projeto: | FCT - Praxis XXI project 2/2.2/SAU/1194/95 BIOMED II (MACE Project) COST Chemistry D8 Program of the European Union I’Association pour a Recherche contre le Cancer (ARC) |
Título da revista, periódico, livro ou evento: | Metal-Based Drugs | Volume: | 5 | Número: | 5 | Resumo: | Aiming at radiopharmaceutical application, (111)In(3+) complexes of the polyaminocarboxylates TTHA, TTHA-bis(butylamide) and TTHA-bis(glucamide) were investigated. The in vitro stability of (111)In(TTHA)(3-) and (111)In(TTHA-bis(butylamide)(-) was evaluated by measuring the exchange of (111)In(3+) from the complexes to transferrin and the results were compared with those for (111)In(DTPA)(2-). We also performed biodistribution studies of the three (111)In(3+) complexes by gamma-imaging in Wistar rats and by measuring the radioactivity in their organs. TTHA and its derivatives seem to have similar in vivo biodistribution with prevailing renal excretion. | URI: | https://hdl.handle.net/10316/110976 | ISSN: | 0793-0291 | DOI: | 10.1155/MBD.1998.259 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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In-vitro-and-in-vivo-behaviour-of-sup111supIn-complexes-of-TTHA-TTHAbisbutylamide-and-TTHAbisglucamide-Stability-biodistribution-and-excretion-studied-by-gamma-imagingMetalBased-Drugs.pdf | 723.45 kB | Adobe PDF | Ver/Abrir |
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