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https://hdl.handle.net/10316/111171
Título: | Photodynamic therapy changes tumour immunogenicity and promotes immune-checkpoint blockade response, particularly when combined with micromechanical priming | Autor: | Lobo, Catarina S. Mendes, Maria Inês P. Pereira, Diogo A. Silva, Lígia C. Gomes da Arnaut, Luís G. |
Data: | 19-Jul-2023 | Editora: | Springer Nature | Projeto: | UID/QUI/00313/2019 ROTEIRO/0152/2013 PTDC/QUI-OUT/0303/2021 FCT scholarship PD/ BD/132524/2017 FCT scholarship PD/BD/143129/2019 |
Título da revista, periódico, livro ou evento: | Scientific Reports | Volume: | 13 | Número: | 1 | Resumo: | Photodynamic therapy (PDT) with redaporfin stimulates colon carcinoma (CT26), breast (4T1) and melanoma (B16F10) cells to display high levels of CD80 molecules on their surfaces. CD80 overexpression amplifies immunogenicity because it increases same cell (cis) CD80:PD-L1 interactions, which (i) disrupt binding of T-cells PD-1 inhibitory receptors with their ligands (PD-L1) in tumour cells, and (ii) inhibit CTLA-4 inhibitory receptors binding to CD80 in tumour cells. In some cancer cells, redaporfin-PDT also increases CTLA-4 and PD-L1 expressions and virtuous combinations between PDT and immune-checkpoint blockers (ICB) depend on CD80/PD-L1 or CD80/CTLA-4 tumour overexpression ratios post-PDT. This was confirmed using anti-CTLA-4 + PDT combinations to increase survival of mice bearing CT26 tumours, and to regress lung metastases observed with bioluminescence in mice with orthotopic 4T1 tumours. However, the primary 4T1 responded poorly to treatments. Photoacoustic imaging revealed low infiltration of redaporfin in the tumour. Priming the primary tumour with high-intensity (~ 60 bar) photoacoustic waves generated with nanosecond-pulsed lasers and light-to-pressure transducers improved the response of 4T1 tumours to PDT. Penetration-resistant tumours require a combination of approaches to respond to treatments: tumour priming to facilitate drug infiltration, PDT for a strong local effect and a change in immunogenicity, and immunotherapy for a systemic effect. | URI: | https://hdl.handle.net/10316/111171 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-023-38862-8 | Direitos: | openAccess |
Aparece nas coleções: | I&D CQC - Artigos em Revistas Internacionais |
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Photodynamic-therapy-changes-tumour-immunogenicity-and-promotes-immunecheckpoint-blockade-response-particularly-when-combined-with-micromechanical-primingScientific-Reports.pdf | 9.35 MB | Adobe PDF | Ver/Abrir |
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