Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113627
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Silva, Jorge M. Alves | - |
dc.contributor.author | Pedreiro, Sónia | - |
dc.contributor.author | Cavaleiro, Carlos | - |
dc.contributor.author | Cruz, M. Teresa | - |
dc.contributor.author | Figueirinha, Artur | - |
dc.contributor.author | Salgueiro, Lígia | - |
dc.date.accessioned | 2024-02-23T11:06:10Z | - |
dc.date.available | 2024-02-23T11:06:10Z | - |
dc.date.issued | 2023-04-17 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://hdl.handle.net/10316/113627 | - |
dc.description.abstract | Aromatic plants are reported to display pharmacological properties, including anti-aging. This work aims to disclose the anti-aging effect of the essential oil (EO) of Thymbra capitata (L.) Cav., an aromatic and medicinal plant widely used as a spice, as well as of the hydrodistillation residual water (HRW), a discarded by-product of EO hydrodistillation. The phytochemical characterization of EO and HRW was assessed by GC-MS and HPLC-PDA-ESI-MSn, respectively. The DPPH, ABTS, and FRAP assays were used to disclose the antioxidant properties. The anti-inflammatory potential was evaluated using lipopolysaccharide-stimulated macrophages by assessing NO production, iNOS, and pro-IL-1β protein levels. Cell migration was evaluated using the scratch wound assay, and the etoposide-induced senescence was used to assess the modulation of senescence. The EO is mainly characterized by carvacrol, while the HRW is predominantly characterized by rosmarinic acid. The HRW exerts a stronger antioxidant effect in the DPPH and FRAP assays, whereas the EO was the most active sample in the ABTS assay. Both extracts reduce NO, iNOS, and pro-IL-1β. The EO has no effect on cell migration and presents anti-senescence effects. In opposition, HRW reduces cell migration and induces cellular senescence. Overall, our study highlights interesting pharmacological properties for both extracts, EO being of interest as an anti-aging ingredient and HRW relevant in cancer therapy. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | UIDP/04539/2020 | pt |
dc.relation | LA/P/0058/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | aging | pt |
dc.subject | phytochemical composition | pt |
dc.subject | inflammatory mediators | pt |
dc.subject | essential oil | pt |
dc.subject | hydrodistillation residual water | pt |
dc.title | Effect of Thymbra capitata (L.) Cav. on Inflammation, Senescence and Cell Migration | pt |
dc.type | article | pt |
degois.publication.firstPage | 1930 | pt |
degois.publication.issue | 8 | pt |
degois.publication.title | Nutrients | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/nu15081930 | - |
degois.publication.volume | 15 | pt |
dc.date.embargo | 2023-04-17 | * |
dc.identifier.pmid | 37111149 | - |
uc.date.periodoEmbargo | 0 | pt |
dc.identifier.eissn | 2072-6643 | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - Associate Laboratory | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CIEPQPF – Chemical Process Engineering and Forest Products Research Centre | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-5270-3993 | - |
crisitem.author.orcid | 0000-0002-5937-1127 | - |
crisitem.author.orcid | 0000-0001-9846-6754 | - |
crisitem.author.orcid | 0000-0003-3064-5718 | - |
crisitem.author.orcid | 0000-0003-0948-821X | - |
Appears in Collections: | FCTUC Eng.Química - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais I&D CERES - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Effect-of-Thymbra-capitata-L-Cav-on-Inflammation-Senescence-and-Cell-MigrationNutrients.pdf | 3.13 MB | Adobe PDF | View/Open |
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