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https://hdl.handle.net/10316/113627
Título: | Effect of Thymbra capitata (L.) Cav. on Inflammation, Senescence and Cell Migration | Autor: | Silva, Jorge M. Alves Pedreiro, Sónia Cavaleiro, Carlos Cruz, M. Teresa Figueirinha, Artur Salgueiro, Lígia |
Palavras-chave: | aging; phytochemical composition; inflammatory mediators; essential oil; hydrodistillation residual water | Data: | 17-Abr-2023 | Editora: | MDPI | Projeto: | UIDB/04539/2020 UIDP/04539/2020 LA/P/0058/2020 |
Título da revista, periódico, livro ou evento: | Nutrients | Volume: | 15 | Número: | 8 | Resumo: | Aromatic plants are reported to display pharmacological properties, including anti-aging. This work aims to disclose the anti-aging effect of the essential oil (EO) of Thymbra capitata (L.) Cav., an aromatic and medicinal plant widely used as a spice, as well as of the hydrodistillation residual water (HRW), a discarded by-product of EO hydrodistillation. The phytochemical characterization of EO and HRW was assessed by GC-MS and HPLC-PDA-ESI-MSn, respectively. The DPPH, ABTS, and FRAP assays were used to disclose the antioxidant properties. The anti-inflammatory potential was evaluated using lipopolysaccharide-stimulated macrophages by assessing NO production, iNOS, and pro-IL-1β protein levels. Cell migration was evaluated using the scratch wound assay, and the etoposide-induced senescence was used to assess the modulation of senescence. The EO is mainly characterized by carvacrol, while the HRW is predominantly characterized by rosmarinic acid. The HRW exerts a stronger antioxidant effect in the DPPH and FRAP assays, whereas the EO was the most active sample in the ABTS assay. Both extracts reduce NO, iNOS, and pro-IL-1β. The EO has no effect on cell migration and presents anti-senescence effects. In opposition, HRW reduces cell migration and induces cellular senescence. Overall, our study highlights interesting pharmacological properties for both extracts, EO being of interest as an anti-aging ingredient and HRW relevant in cancer therapy. | URI: | https://hdl.handle.net/10316/113627 | ISSN: | 2072-6643 | DOI: | 10.3390/nu15081930 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Eng.Química - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais I&D CERES - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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Effect-of-Thymbra-capitata-L-Cav-on-Inflammation-Senescence-and-Cell-MigrationNutrients.pdf | 3.13 MB | Adobe PDF | Ver/Abrir |
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